Title:
治療用分子を送達するためのカチオン性両親媒性物質と共脂質とを含む組成物
Document Type and Number:
Japanese Patent JP2012526858
Kind Code:
A
Abstract:
This disclosure provides compositions consisting of solid mixture of cationic lipids and a polynucleotide, wherein the cationic lipid molecules form a water-insoluble ionic complex with the polynucleotide. What is also described is an anhydrous mixture of the cationic lipids and the polynucleotide solubilized in an organic or polar aprotic solvent. The anhydrous compositions are useful in preparing therapeutic formulations and in the diagnosis and treatment of diseases and conditions. The compositions are useful for delivery of agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.
Inventors:
Kunyuan Cui
Dong Liang
David Sweedler
Dong Liang
David Sweedler
Application Number:
JP2012511923A
Publication Date:
November 01, 2012
Filing Date:
May 16, 2010
Export Citation:
Assignee:
Kunyuan Cui
Dong Liang
David Sweedler
Dong Liang
David Sweedler
International Classes:
A61K31/7088; A61K9/08; A61K31/713; A61K47/24; A61K47/28; A61K47/34; A61K47/48; A61K48/00
Domestic Patent References:
| JP2002524473A | 2002-08-06 |
Foreign References:
| WO2002087541A1 | 2002-11-07 |
Other References:
JPN6014019111; ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ １３１（１０）, 200903, ｐ．３４４０-３４４１
JPN6014019112; ＬＡＮＧＭＵＩＲ １５（６）, 1999, ｐ．１９２３-１９２８
JPN6014019113; ＢＩＯＣＨＩＭＩＣＡ ＥＴ ＢＩＯＰＨＹＳＩＣＡ ＡＣＴＡ １７７８（１）, 2008, ｐ．２１４-２２８
JPN6014019114; ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ １２０, 1998, ｐ．６１６５-６１６６
JPN6014019112; ＬＡＮＧＭＵＩＲ １５（６）, 1999, ｐ．１９２３-１９２８
JPN6014019113; ＢＩＯＣＨＩＭＩＣＡ ＥＴ ＢＩＯＰＨＹＳＩＣＡ ＡＣＴＡ １７７８（１）, 2008, ｐ．２１４-２２８
JPN6014019114; ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ １２０, 1998, ｐ．６１６５-６１６６
Attorney, Agent or Firm:
Takuya Kuno
Takahashi
Kiyoshi Kuruma
Kimihiro Hoshi
Hiroyasu Ninomiya
Shuichi Sumiyoshi
Ryoichi Shino
Ueshima
Yasushi Miyagi
Einzel Felix-Reinhard
Takahashi
Kiyoshi Kuruma
Kimihiro Hoshi
Hiroyasu Ninomiya
Shuichi Sumiyoshi
Ryoichi Shino
Ueshima
Yasushi Miyagi
Einzel Felix-Reinhard