Title:
尿酸ホメオスタシスのコントロール
Document Type and Number:
Japanese Patent JP2012527219
Kind Code:
A
Abstract:
The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to uric acid. In a particular embodiment the invention relates to a mammalian cell useful in detecting and/or degrading a harmful excess of uric acid comprising (a) a vector comprising a genetic code for the uricase sensor-regulator HucR from Deinococcus radiodurans R1 fused to a transactivation domain or a transrepressor domain; and (b) a vector comprising the corresponding operator sequence hucO from Deinococcus radiodurans R1 specifically binding the bacterial uric acid sensor-regulator HucR, a promoter and a polynucleotide coding for an endogenous or exogenous protein, e.g. a protein interacting with uric acid.
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Inventors:
Kemer, christian
Weber, Wilfried
Husseneger, Martin
Weber, Wilfried
Husseneger, Martin
Application Number:
JP2012511166A
Publication Date:
November 08, 2012
Filing Date:
May 06, 2010
Export Citation:
Assignee:
ETH Zurich
International Classes:
C12N15/09; A01K67/027; A61K35/12; A61P19/06; C12N5/10
Attorney, Agent or Firm:
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa