Title:
抗癌活性を有するシクロアルタノン誘導体
Document Type and Number:
Japanese Patent JP2012527433
Kind Code:
A
Abstract:
The present invention relates to a compound of following formula (I): or to a pharmaceutically acceptable salt thereof, as well as to pharmaceutical compositions including same and to the use thereof as a drug, in particular for treating a proliferative disease such as cancer.
Inventors:
Christoph, Ron
Eve, Guminski
Fadilla, Del Guini
Josephine, Beck
Frederick, Cantagrel
Eve, Guminski
Fadilla, Del Guini
Josephine, Beck
Frederick, Cantagrel
Application Number:
JP2012511302A
Publication Date:
November 08, 2012
Filing Date:
May 20, 2010
Export Citation:
Assignee:
Pierre, Fabre, Medicaman
Centre National De La Recherche Scientifique (C.N.R.S)
Centre National De La Recherche Scientifique (C.N.R.S)
International Classes:
C07J53/00; A61K31/56; A61K31/58; A61K31/585; A61P35/00; C07F7/08; C07F7/18; C07F9/09; C07J71/00
Foreign References:
| WO2002053138A2 | 2002-07-11 | |||
| WO2011003284A1 | 2011-01-13 | |||
| WO2002053138A2 | 2002-07-11 |
Other References:
JPN6014026435; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ６５（１２）, 2002, １８８６-１８９１
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
JPN6014050974; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ６４（１１）, 2001, １４５１-１４５３
JPN6014026435; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ６５（１２）, 2002, １８８６-１８９１
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
JPN6014050974; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ６４（１１）, 2001, １４５１-１４５３
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
JPN6014050974; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ６４（１１）, 2001, １４５１-１４５３
JPN6014026435; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ６５（１２）, 2002, １８８６-１８９１
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
JPN6014050974; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ６４（１１）, 2001, １４５１-１４５３
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
JPN6014026432; Ｊｏｕｒｎａｌ ｏｆ Ｎａｔｕｒａｌ Ｐｒｏｄｕｃｔｓ ７０（６）, 2007, ９１８-９２２
JPN5012013693; ＧＲＡＮＤＯ， ＲＯＧＥＲＩＯ: 'ＡＮＴＩＮＥＯＰＬＡＳＴＩＣ ３１-ＮＯＲＣＹＣＬＯＡＲＴＡＮＯＮＥＳ ＦＲＯＭ ＳＯＬＡＮＵＭ ＣＥＲＮＵＵＭ ＶＥＬＬ' ＺＥＩＴＳＣＨＲＩＦＴ ＦＵＥＲ ＮＡＴＵＲＦＯＲＳＣＨＵＮＧ Ｖ６３ Ｎ７／８, 2008, Ｐ５０７-５１４
JPN5012013694; ＲＡＫＨＩＭＯＶ Ｋ Ｄ: 'ＴＲＩＴＥＲＰＥＮＥ ＧＬＹＣＯＳＩＤＥＳ ＦＲＯＭ ＴＨＡＬＩＣＴＲＵＭ-ＦＯＥＴＩＤＵＭ Ｌ． ＡＮＤ ＴＨＡＬＩＣＴＲＵＭ-ＭＩＮＵＳ Ｌ． 以下備考' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＪＯＵＲＮＡＬ Ｖ２１ Ｎ１２, 1987, Ｐ８４８-８５０
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Hiroshi Sorimachi
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Hiroshi Sorimachi