Title:
増殖性および病原性疾患の治療のための方法および組成物
Document Type and Number:
Japanese Patent JP2013502428
Kind Code:
A
Abstract:
The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of the Streptococcus intermedins intermedilysin (ILY) protein. In order to prevent the independent induction of CDC and ADCC, the antibodies of the invention can bind the same hCD59 epitope as ILYd4 and/or contain modifications that disrupt the interaction between the antibody and complement.
Inventors:
Chin, Shwebin
Fu, Wei Guo
Fu, Wei Guo
Application Number:
JP2012525663A
Publication Date:
January 24, 2013
Filing Date:
August 18, 2010
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C07K16/30; A61K38/00; A61K39/12; A61K39/145; A61K39/21; A61K39/245; A61K39/29; A61K39/395; A61P31/12; A61P31/16; A61P31/18; A61P35/00; A61P35/02; A61P43/00; C07K16/08; C07K16/12; C12N15/02; C12N15/09; C12P21/08
Domestic Patent References:
| JP2002502595A | 2002-01-29 |
Other References:
JPN5012016482; ＧＩＤＤＩＮＧＳ: 'ＨＵＭＡＮ ＣＤ５９ ＩＳ Ａ ＲＥＣＥＰＴＯＲ ＦＯＲ ＴＨＥ ＣＨＯＬＥＳＴＥＲＯＬ-ＤＥＰＥＮＤＥＮＴ ＣＹＴＯＬＹＳＩＮ ＩＮＴＥＲＭＥＤＩＬＹＳＩＮ' ＮＡＴ ＳＴＲＵＣＴ ＭＯＬ ＢＩＯＬ Ｖ１１ Ｎ１２, 2004, Ｐ１１７３-１１７８
JPN5012016484; ＩＡＮＮＥＬＬＯ: 'ＲＯＬＥ ＯＦ ＡＮＴＩＢＯＤＹ-ＤＥＰＥＮＤＥＮＴ ＣＥＬＬ-ＭＥＤＩＡＴＥＤ ＣＹＴＯＴＯＸＩＣＩＴＹ ＩＮ ＴＨＥ ＥＦＦＩＣＡＣＹ 以下備考' ＣＡＮＣＥＲ ＡＮＤ ＭＥＴＡＳＴＡＳＩＳ ＲＥＶＩＥＷＳ Ｖ２４, 2005, Ｐ４８７-４９９
JPN6014043407; ＦＡＳＥＢ Ｊ． （２００８） ｖｏｌ．２２， Ｍｅｅｔｉｎｇ Ａｂｓｔｒａｃｔｓ， ｐ．５２２
JPN5012016484; ＩＡＮＮＥＬＬＯ: 'ＲＯＬＥ ＯＦ ＡＮＴＩＢＯＤＹ-ＤＥＰＥＮＤＥＮＴ ＣＥＬＬ-ＭＥＤＩＡＴＥＤ ＣＹＴＯＴＯＸＩＣＩＴＹ ＩＮ ＴＨＥ ＥＦＦＩＣＡＣＹ 以下備考' ＣＡＮＣＥＲ ＡＮＤ ＭＥＴＡＳＴＡＳＩＳ ＲＥＶＩＥＷＳ Ｖ２４, 2005, Ｐ４８７-４９９
JPN6014043407; ＦＡＳＥＢ Ｊ． （２００８） ｖｏｌ．２２， Ｍｅｅｔｉｎｇ Ａｂｓｔｒａｃｔｓ， ｐ．５２２
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Kosemura Akiko
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Kosemura Akiko