Title:
小脳でのGABA放出調節剤
Document Type and Number:
Japanese Patent JP2013502455
Kind Code:
A
Abstract:
A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1 (Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.
Inventors:
Lee, Chang Jun Justin
Lee Soo-John
Boon
Lee Soo-John
Boon
Application Number:
JP2012526640A
Publication Date:
January 24, 2013
Filing Date:
August 24, 2010
Export Citation:
Assignee:
Korea Institute of Science and Technology
International Classes:
A61K45/00; A61K31/196; A61K31/26; A61K31/455; A61K31/7088; A61K31/7105; A61K38/00; A61K38/095; A61K38/17; A61K48/00; A61P5/00; A61P9/10; A61P25/00; A61P25/08; A61P25/14; A61P25/20; A61P25/28; A61P25/32; A61P43/00; G01N33/15; G01N33/50; C12N15/09; C12N15/113
Foreign References:
| WO2009096612A1 | 2009-08-06 |
Other References:
JPN6013039532; Ｄ． Ｊ． Ｒｏｓｓｉ， ｅｔ ａｌ．， Ｊｏｕｒｎａｌ ｏｆ Ｐｈｙｓｉｏｌｏｇｙ， ２００３， ５４８（１）， ｐｐ９７-１１０
Attorney, Agent or Firm:
Kenzo Hara International Patent Office