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Title:
脂質、脂質組成物およびそれらの使用方法
Document Type and Number:
Japanese Patent JP2013515693
Kind Code:
A
Abstract:
Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.

Inventors:
Jeremy Barryza
Keith Bowman
Andrew Gale
Tangina Fazar
Cameron Lee
Chandra Burgis
Laura West
Jao Junpin
Application Number:
JP2012545302A
Publication Date:
May 09, 2013
Filing Date:
December 21, 2010
Export Citation:
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Assignee:
Novartis Age
International Classes:
A61K47/28; A61K31/7105; A61K45/00; A61K47/34; A61K48/00; A61P1/16; A61P35/00; C07J9/00; C07J43/00; C08G65/333
Domestic Patent References:
JP2009520039A2009-05-21
JPS5179734A1976-07-12
JP2002212477A2002-07-31
JP2008530215A2008-08-07
JP2009509566A2009-03-12
JP2008504827A2008-02-21
Foreign References:
WO2008147438A22008-12-04
WO2008103276A22008-08-28
WO2009082817A12009-07-09
CN101468203A2009-07-01
CN1311189A2001-09-05
WO2008011431A22008-01-24
WO2009051451A22009-04-23
WO2009086558A12009-07-09
Other References:
HUAN XU ET AL.: "Esterase-catalyzed dePEGylation of pH-sensitive vesicles modified with cleavable PEG-lipid derivativ", JOURNAL OF CONTROLLED RELEASE, vol. 130, JPN6015021266, 17 May 2008 (2008-05-17), pages 238 - 245, ISSN: 0003084909
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai



 
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