Title:
対立遺伝子多様体の選択的低減
Document Type and Number:
Japanese Patent JP2013518605
Kind Code:
A
Abstract:
Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a huntingtin gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate Huntington's Disease (HD).
Inventors:
Bennett, Sea Frank
Hayden, Michael
Flair, Susan M
Sarah Greenley
Carroll, jeffrey
Warby, simon
Swayze, Eric Y
Hayden, Michael
Flair, Susan M
Sarah Greenley
Carroll, jeffrey
Warby, simon
Swayze, Eric Y
Application Number:
JP2012552933A
Publication Date:
May 23, 2013
Filing Date:
February 08, 2011
Export Citation:
Assignee:
Isis Pharmaceuticals, Inc.
International Classes:
C12N15/09; A61K31/7088; A61K31/7115; A61K31/712; A61K31/7125; A61P25/14; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50
Domestic Patent References:
| JP2008513507A | 2008-05-01 |
Foreign References:
| WO2009135322A1 | 2009-11-12 | |||
| WO2008005562A2 | 2008-01-10 |
Other References:
EXPERIMENTAL NEUROLOGY, vol. 217, JPN6015015949, 2009, pages 312 - 319, ISSN: 0003392169
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Norihiro Fukasawa
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Norihiro Fukasawa