Title:
式(I)のpan-CDK阻害剤の調製のための方法、および該調製における中間体
Document Type and Number:
Japanese Patent JP2013542189
Kind Code:
A
Abstract:
The invention relates to a novel process for the preparation of pan-CDK inhibitors of the formula (I), and intermediates of the preparation.
More Like This:
Inventors:
Joachim Kruger
Jörg Grease
Ky Rovis
Jorma Hasfelt
Jörg Grease
Ky Rovis
Jorma Hasfelt
Application Number:
JP2013529628A
Publication Date:
November 21, 2013
Filing Date:
September 20, 2011
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
International Classes:
C07D239/47; C07C69/78; C07C381/10; A61K31/505; A61P35/00; A61P43/00; C07B61/00
Domestic Patent References:
| JP2010530396A | 2010-09-09 | |||
| JP2009520740A | 2009-05-28 | |||
| JP2010530396A | 2010-09-09 | |||
| JP2009520740A | 2009-05-28 |
Foreign References:
| WO2010046035A1 | 2010-04-29 | |||
| WO2010046035A1 | 2010-04-29 |
Other References:
JPN6015022512; ＴＯＭＯＯＫＡ，Ｃ．Ｓ． ｅｔ ａｌ: 'Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ ｎｉｔｒｏｇｅｎ ｔｒａｎｓｆｅｒ ｔｏ ｓｕｌｆｉｄｅｓ ｆｒｏｍ ｎｉｔｒｉｄｏｍａｎｇａｎｅｓｅ（Ｖ） ｃｏｍｐｌｅｘｅｓ' Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．８５， Ｎｏ．１１, 2002, ｐ．３７７３-３７８４
JPN6015022513; ＷＡＬＫＥＲ，Ｄ．Ｐ． ｅｔ ａｌ: 'Ｓｕｌｆｏｘｉｍｉｎｅ-ｓｕｂｓｔｉｔｕｔｅｄ ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌｐｙｒｉｍｉｄｉｎｅ ａｎａｌｏｇｓ ａｓ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｐｒｏｌｉｎｅ-ｒｉｃｈ ｔｙｒｏｓｉｎｅ ｋｉｎ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１９， Ｎｏ．１２, 2009, ｐ．３２５３-３２５８
JPN6015022512; ＴＯＭＯＯＫＡ，Ｃ．Ｓ． ｅｔ ａｌ: 'Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ ｎｉｔｒｏｇｅｎ ｔｒａｎｓｆｅｒ ｔｏ ｓｕｌｆｉｄｅｓ ｆｒｏｍ ｎｉｔｒｉｄｏｍａｎｇａｎｅｓｅ（Ｖ） ｃｏｍｐｌｅｘｅｓ' Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．８５， Ｎｏ．１１, 2002, ｐ．３７７３-３７８４
JPN6015022513; ＷＡＬＫＥＲ，Ｄ．Ｐ． ｅｔ ａｌ: 'Ｓｕｌｆｏｘｉｍｉｎｅ-ｓｕｂｓｔｉｔｕｔｅｄ ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌｐｙｒｉｍｉｄｉｎｅ ａｎａｌｏｇｓ ａｓ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｐｒｏｌｉｎｅ-ｒｉｃｈ ｔｙｒｏｓｉｎｅ ｋｉｎ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１９， Ｎｏ．１２, 2009, ｐ．３２５３-３２５８
JPN6015022513; ＷＡＬＫＥＲ，Ｄ．Ｐ． ｅｔ ａｌ: 'Ｓｕｌｆｏｘｉｍｉｎｅ-ｓｕｂｓｔｉｔｕｔｅｄ ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌｐｙｒｉｍｉｄｉｎｅ ａｎａｌｏｇｓ ａｓ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｐｒｏｌｉｎｅ-ｒｉｃｈ ｔｙｒｏｓｉｎｅ ｋｉｎ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１９， Ｎｏ．１２, 2009, ｐ．３２５３-３２５８
JPN6015022512; ＴＯＭＯＯＫＡ，Ｃ．Ｓ． ｅｔ ａｌ: 'Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ ｎｉｔｒｏｇｅｎ ｔｒａｎｓｆｅｒ ｔｏ ｓｕｌｆｉｄｅｓ ｆｒｏｍ ｎｉｔｒｉｄｏｍａｎｇａｎｅｓｅ（Ｖ） ｃｏｍｐｌｅｘｅｓ' Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．８５， Ｎｏ．１１, 2002, ｐ．３７７３-３７８４
JPN6015022513; ＷＡＬＫＥＲ，Ｄ．Ｐ． ｅｔ ａｌ: 'Ｓｕｌｆｏｘｉｍｉｎｅ-ｓｕｂｓｔｉｔｕｔｅｄ ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌｐｙｒｉｍｉｄｉｎｅ ａｎａｌｏｇｓ ａｓ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｐｒｏｌｉｎｅ-ｒｉｃｈ ｔｙｒｏｓｉｎｅ ｋｉｎ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１９， Ｎｏ．１２, 2009, ｐ．３２５３-３２５８
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mina Shiga
Takuji Yamada
Michiko Matsutani
Mina Shiga