Title:
オリゴヌクレオチド送達用の新規低分子量カチオン性脂質
Document Type and Number:
Japanese Patent JP2013545727
Kind Code:
A
Abstract:
Provided are cationic lipids that can be used in combination with other lipid components, such as cholesterol and PEG-lipids, to form lipid nanoparticles with oligonucleotides,in particular siRNA. Such cationic lipids have low molecular weight and compriseg at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA. The cationic lipid scaffold which they fom has enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver.
Inventors:
Collective, Stephen El
Stanton, Machine G
Stanton, Machine G
Application Number:
JP2013534981A
Publication Date:
December 26, 2013
Filing Date:
October 17, 2011
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07C229/12; A61K31/7105; A61K31/713; A61K47/18; A61K48/00; C12N15/09
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama