Title:
ベンジルアミン化合物から2,2-ジフルオロエチルアミンを調製する方法
Document Type and Number:
Japanese Patent JP2014500253
Kind Code:
A
Abstract:
Process for the preparation of 2,2-difluoroethylamine of the formula (I) CHF2CH2NH2(I) comprising the stages (i) and (ii): stage (i): reaction of 2,2-difluoro-1-haloethane of the general formula (II) CHF2-CH2Hal(II), with a benzylamine compound of the formula (III) in the presence of an acid scavenger, in which, in formula (II), Hal is chlorine, bromine or iodine, and, in the formulae (III), R1 is hydrogen or C1-C12-alkyl, and R2 is hydrogen, halogen, C1-C12-alkyl or C1-C6-alkoxy; stage (ii): catalytic hydrogenation of the N-benzyl-2,2-difluoroethanamine compound obtained in the stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.
Inventors:
Louis, Norbert
Heinrich, Yenz-Datemar
Funke, Cristian
Schlegel, Guyunter
Miura, Thomas Norbert
Heinrich, Yenz-Datemar
Funke, Cristian
Schlegel, Guyunter
Miura, Thomas Norbert
Application Number:
JP2013538145A
Publication Date:
January 09, 2014
Filing Date:
November 07, 2011
Export Citation:
Assignee:
Bayer Intellectual Property GMBH
International Classes:
C07C209/62; C07C211/15; C07B61/00
Domestic Patent References:
| JPH06157430A | 1994-06-03 | |||
| JP2005263772A | 2005-09-29 | |||
| JPS5544048B1 | 1980-11-10 | |||
| JPH06157430A | 1994-06-03 |
Foreign References:
| CN101638370A | 2010-02-03 |
Other References:
JPN6015024640; Ｋａｚｕｍａｓａ Ａｏｋｉ ａｎｄ Ｋｅｎｊｉ Ｋｏｇａ: 'Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ Ｄｅｐｒｏｔｏｎａｔｉｏｎ ｏｆ ４-ｔｅｒｔ-Ｂｕｔｙｌｃｙｃｌｏｈｅｘａｎｏｎｅ ｂｙ Ｆｌｕｏｒｉｎｅ-Ｃｏｎｔａｉｎｉｎｇ Ｃｈｉｒａｌ Ｌｉｔｈｉｕｍ Ａｍ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌｕｍｅ ３８， Ｉｓｓｕｅ １４, 1997, ｐｐ．２５０５-２５０６
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama