病原体−宿主相互作用を阻害する糖模倣体 - University of Georgia Research Foundation, Incorporated

Title:

病原体−宿主相互作用を阻害する糖模倣体

Document Type and Number:

Japanese Patent JP2015518464

Kind Code:

A

Abstract:

本発明は、細胞表面シアル酸付加ガラクトースに対する様々な病原体の結合を阻害するよう合理的に設計された新規な化合物、及びその使用方法に関する。詳細には、隣接する単糖残基を有するラクタム環構造又は環式エーテル／アミン環構造を形成するシアル酸グリコシド及びＣ−グリコシドを開示する。

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Inventors:

Woods, Robert, Jay.
Murphy, Paul, Buoy.
Jan, Loretta
Smith, Hana, M., Kay.
Jennifer Handel

Application Number:

JP2015500601A

Publication Date:

July 02, 2015

Filing Date:

March 14, 2013

Export Citation:

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Assignee:

University of Georgia Research Foundation, Incorporated
National University of Ireland, Galway
Glycosensors and Diagnostics, LRC.

International Classes:

C07H7/06; A61K31/706; A61L2/18; A61P31/00; A61P31/04; A61P31/12; A61P31/16; A61P33/02; A61P43/00; D06M15/03

Domestic Patent References:

JP2001131074A

2001-05-15

Foreign References:

US4510317A

1985-04-09

Other References:

JOURNAL OF ORGANIC CHEMISTRY, vol. 69, no. 20, JPN6017010685, 2004, pages 6900 - 6903, ISSN: 0003528920
INFECTION AND IMMUNITY, vol. 65, no. 2, JPN6017010687, 1997, pages 750 - 757, ISSN: 0003528921
NATURE REVIEWS DRUG DISCOVERY, vol. 6, JPN6017010689, 2007, pages 967 - 974, ISSN: 0003528922

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta

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