Title:
肝臓癌治療のためのヌクレオチド類
Document Type and Number:
Japanese Patent JP2017504572
Kind Code:
A
Abstract:
本発明では、肝細胞癌、胆管癌、または胆道癌などの肝臓癌の治療のための化合物、組成物および方法が提供される。ある種の実施形態において、ヌクレオシド誘導体の化合物および組成物が開示され、それは単独でまたは他の抗癌剤と組み合わせて投与することができる。ある種の実施形態において、当該化合物は、式Ｉ：（Ｉ）のヌクレオシド類縁体またはそれの医薬として許容される塩（式中、「塩基」、Ｚ１、Ｚ２、Ｚ３、Ｚ４、Ｖ、Ｗ、Ｘ、Ａｒ、Ｒ１およびＲ２は本明細書に記載の通りである。）である。【化１】
Inventors:
Dowson, Cyril Be
Dauhan, Davoid
Parsui, Christoph Claude
Dauhan, Davoid
Parsui, Christoph Claude
Application Number:
JP2016535003A
Publication Date:
February 09, 2017
Filing Date:
November 25, 2014
Export Citation:
Assignee:
IDENIX PHARMACEUTICALS LRC
International Classes:
C07H19/10; A61K31/675; A61K31/7068; A61K31/708; A61P1/16; A61P35/00; C07F9/6558; C07F9/6561; C07H19/20
Domestic Patent References:
| JP2006528162A | 2006-12-14 | |||
| JP2008533191A | 2008-08-21 |
Foreign References:
| WO2007056596A2 | 2007-05-18 |
Other References:
WEI SHEN, JAE-SEUNG KIM, PHILLIP E. KISH, JIE ZHANG, STEFANIE MITCHELL, BRIAN G. GENTRY, JULIE M. BR: "Design and synthesis of vidarabine prodrugs as antiviral agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, JPN6018049343, 2009, pages 792 - 796, ISSN: 0004069692
YOUCEF MEHELLOU, ROCCO VALENTE, HUW MOTTRAM, ELISABETH WALSBY, KENNETH I. MILLS, JAN BALZARINI, CHRI: "Phosphoramidates of 2'-β-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, JPN6018049345, 2010, pages 2439 - 2446, XP027027250, ISSN: 0004069693
YOUCEF MEHELLOU, ROCCO VALENTE, HUW MOTTRAM, ELISABETH WALSBY, KENNETH I. MILLS, JAN BALZARINI, CHRI: "Phosphoramidates of 2'-β-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, JPN6018049345, 2010, pages 2439 - 2446, XP027027250, ISSN: 0004069693
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama