Title:
改変κ軽鎖結合ポリペプチド
Document Type and Number:
Japanese Patent JP2017537632
Kind Code:
A
Abstract:
本発明は、配列番号２〜６又は１２で定義されるか、又はそれらと９５％以上又は９８％の配列相同性を有する親ドメインの１以上のアスパラギン残基が、アスパラギンでも、プロリンでも、システインでもない別のアミノ酸残基に変異されている、ＰｅｐｔｏｓｔｒｅｐｔｏｃｏｃｃｕｓのプロテインＬの変異結合ドメインを含むκ軽鎖結合ポリペプチドを開示する。【選択図】図３
Inventors:
Rodrigo, Gustav
Andel, Mats
Björkman, Thomas
Andel, Mats
Björkman, Thomas
Application Number:
JP2017530111A
Publication Date:
December 21, 2017
Filing Date:
December 11, 2015
Export Citation:
Assignee:
GE Healthcare Bioprocess R&D Actibolag
International Classes:
C12N15/09; C07K1/22; C07K14/195; C07K17/00
Domestic Patent References:
| JPH07506573A | 1995-07-20 |
Other References:
LINHULT MARTIN: "IMPROVING THE TOLERANCE OF A PROTEIN A ANALOGUE TO REPEATED ALKALINE EXPOSURES USING A 以下備考", PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS, vol. VOL:55, NR:2, JPN5017010796, May 2004 (2004-05-01), US, pages 407 - 416, ISSN: 0004372117
GULICH SUSANNE: "ENGINEERING STREPTOCOCCAL PROTEIN G FOR INCREASED ALKALINE STABILITY", PROTEIN ENGINEERING, vol. VOL:15, NR:10, JPN5017010798, October 2002 (2002-10-01), GB, pages 835 - 842, XP055556696, ISSN: 0004372118, DOI: 10.1093/protein/15.10.835
PALMER B: "DESIGN OF STABILITY AT EXTREME ALKALINE PH IN STREPTOCOCCAL PROTEIN G", JOURNAL OF BIOTECHNOLOGY, vol. VOL:134, NR:3-4, JPN5017010801, 30 April 2008 (2008-04-30), NL, pages 222 - 230, ISSN: 0004372119
GULICH S: "STABILITY TOWARDS ALKALINE CONDITIONS CAN BE ENGINEERED INTO A PROTEIN LIGAND", JOURNAL OF BIOTECHNOLOGY, vol. VOL:80, NR:2, JPN5017010803, 23 June 2000 (2000-06-23), NL, pages 169 - 178, ISSN: 0004372120
GULICH SUSANNE: "ENGINEERING STREPTOCOCCAL PROTEIN G FOR INCREASED ALKALINE STABILITY", PROTEIN ENGINEERING, vol. VOL:15, NR:10, JPN5017010798, October 2002 (2002-10-01), GB, pages 835 - 842, XP055556696, ISSN: 0004372118, DOI: 10.1093/protein/15.10.835
PALMER B: "DESIGN OF STABILITY AT EXTREME ALKALINE PH IN STREPTOCOCCAL PROTEIN G", JOURNAL OF BIOTECHNOLOGY, vol. VOL:134, NR:3-4, JPN5017010801, 30 April 2008 (2008-04-30), NL, pages 222 - 230, ISSN: 0004372119
GULICH S: "STABILITY TOWARDS ALKALINE CONDITIONS CAN BE ENGINEERED INTO A PROTEIN LIGAND", JOURNAL OF BIOTECHNOLOGY, vol. VOL:80, NR:2, JPN5017010803, 23 June 2000 (2000-06-23), NL, pages 169 - 178, ISSN: 0004372120
Attorney, Agent or Firm:
Arakawa Satoshi
Hirokazu Ogura
Toshihisa Kurokawa
Takuto Tanaka
Hirokazu Ogura
Toshihisa Kurokawa
Takuto Tanaka