Title:
EUTECTIC FORMULATIONS OF CYCLOBENZAPRINE HYDROCHLORIDE
Document Type and Number:
Japanese Patent JP2018193409
Kind Code:
A
Abstract:
To provide a composition that increases stability of cyclobenzaprine HCl (in the presence or absence of a basifying agent), and methods for manufacturing such a composition.SOLUTION: The present invention relates to pharmaceutical compositions and methods for manufacturing the pharmaceutical compositions, comprising a eutectic of cyclobenzaprine HCl and mannitol. A compound useful in embodiments of the present invention is cyclobenzaprine HCl. In some embodiments, the compound is micronized. In alternative embodiments, the compound is not micronized. In some embodiments, the compound may be present in one or more crystal isoforms.SELECTED DRAWING: Figure 6
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Inventors:
SETH LEDERMAN
MARINO NEBULONI
MARINO NEBULONI
Application Number:
JP2018173466A
Publication Date:
December 06, 2018
Filing Date:
September 18, 2018
Export Citation:
Assignee:
TONIX PHARMA HOLDINGS LTD
International Classes:
A61K31/137; A61K9/16; A61K9/20; A61K47/02; A61K47/12; A61K47/26; A61P21/00; A61P25/04; A61P25/08; A61P25/20; A61P25/22; A61P25/24
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto