Title:
pirinポリペプチド及び免疫モジュレーション
Document Type and Number:
Japanese Patent JP2018501228
Kind Code:
A
Abstract:
本発明は、対象の障害の治療及び/又は予防に使用するための、ポリペプチドHP、ポリペプチドHPをコードするポリヌクレオチド配列、前記ポリヌクレオチド配列を含む宿主細胞、又は前記ポリヌクレオチド配列を含む発現ベクターを含む宿主細胞であって、前記障害が、炎症性障害及び/又は自己免疫障害であり;前記ポリペプチドが、配列番号2、配列番号4若しくは配列番号6又はそのバリアント、ホモログ、断片若しくは誘導体と少なくとも75%の同一性を有し;かつ前記ポリヌクレオチド配列が、配列番号2、配列番号4若しくは配列番号6又はそのバリアント、ホモログ、断片若しくは誘導体と少なくとも75%の同一性を有するポリペプチドをコードし、及び/又は前記ポリヌクレオチド配列が、配列番号1、配列番号3若しくは配列番号5又はそのバリアント、ホモログ、断片若しくは誘導体と少なくとも75%の同一性を有する;前記ポリペプチドHP前記ポリヌクレオチド配列又は前記宿主細胞に関する。
Inventors:
Kelly Denise
Application Number:
JP2017531232A
Publication Date:
January 18, 2018
Filing Date:
December 22, 2015
Export Citation:
Assignee:
4D PHARMA RESEARCH LIMITED
International Classes:
A61K35/741; A61K9/48; A61K35/744; A61K36/00; A61K36/062; A61K36/064; A61K38/16; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P11/02; A61P11/06; A61P11/08; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P31/00; A61P37/02
Foreign References:
WO2008055703A2 | 2008-05-15 |
Other References:
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PANG,H. ET AL.: "Crystal structure of human pirin: an iron-binding nuclear protein qand transcription cofactor.", J. BIOL. CHEM., vol. 279, no. 2, JPN5017010822, 9 January 2004 (2004-01-09), pages 1941 - 8, XP055246106, DOI: doi:10.1074/jbc.M310022200
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Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita