Title:
線維症の治療のためのセニクリビロック併用療法
Document Type and Number:
Japanese Patent JP2018532720
Kind Code:
A
Abstract:
セニクリビロック（ＣＶＣ）は、Ｃ−Ｃケモカイン受容体５型（ＣＣＲ５）及びＣ−Ｃケモカイン受容体２型（ＣＣＲ２）に結合するリガンドの経口活性アンタゴニストである。ＣＶＣは、ＣＣＲ５へのＲＡＮＴＥＳ、ＭＩＰ−１α、及びＭＩＰ−１βの結合、ならびにＣＣＲ２へのＭＣＰ−１／ＣＣＬ２の結合を遮断する。ケモカインアンタゴニスト、ＦＸＲアゴニスト、高投与量ビタミンＥ（＞４００ｉＵ／ｄ）、ペルオキシソーム増殖因子活性化受容体α（ＰＰＡＲ−α）アゴニスト、ＰＰＡＲ−γアゴニスト、及び／またはＰＰＡＲ−δアゴニストとのＣＶＣの共投与を含む線維症及び関連病態の治療方法を本明細書で提供する。【選択図】図１
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Inventors:
Eric Lefevre
Application Number:
JP2018513847A
Publication Date:
November 08, 2018
Filing Date:
March 16, 2016
Export Citation:
Assignee:
Tobira Therapeutics, Incorporated
International Classes:
A61K31/4178; A61K9/20; A61K31/137; A61K31/235; A61K31/351; A61K31/381; A61K31/40; A61K31/403; A61K31/426; A61K31/437; A61K31/4535; A61K31/4745; A61K31/495; A61K31/496; A61K31/4985; A61K31/506; A61K31/519; A61K31/522; A61K31/55; A61K31/575; A61K31/69; A61K31/7052; A61K38/16; A61K39/395; A61K45/00; A61K47/12; A61P1/16; A61P13/12; A61P43/00; G01N33/68
Domestic Patent References:
| JP2017513634A | 2017-06-01 | |||
| JP2017501137A | 2017-01-12 | |||
| JP2014505049A | 2014-02-27 |
Foreign References:
| US20070015796A1 | 2007-01-18 | |||
| WO2014186581A1 | 2014-11-20 |
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ANTIVIRAL THERAPY - AN OFFICIAL PUBLICAITON OF THE INTERNATIONAL SOCIETY FOR ANTIVIRAL RESEARCH; ABS, vol. 18, no. 3, JPN6018045395, 15 October 2013 (2013-10-15), pages 016, ISSN: 0004547140
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 291, no. 1, JPN6019018477, 2002, pages 55 - 61, ISSN: 0004547146
ENDOCRINOLOGY, vol. 154, no. 5, JPN6019018481, 2013, pages 1794 - 1801, ISSN: 0004547147
日薬理誌, vol. 128, JPN6019018482, 2006, pages 235 - 238, ISSN: 0004547148
"Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-depen", CLIN CHIM ACTA, vol. 381 (2), JPN6019018475, 2007, pages 107 - 113, ISSN: 0004547141
20TH INTERNATIONAL AIDS CONFERENCE, 2014, (オンライン), 検索日[2020.01.09], JPN7020000071, ISSN: 0004193817
AM J PHYSIOL RENAL PHYSIOL, vol. 289, JPN6019018479, 2005, pages 1153 - 1158, ISSN: 0004547151
JOURNAL OF HEPATOLOGY, vol. Vol.62, supp. 2, JPN6020044492, April 2015 (2015-04-01), pages 187 - 01, ISSN: 0004547152
ANNUAL REVIEW 消化器 2001, vol. p.88-93, JPN6021026701, ISSN: 0004547142
PLOS ONE, vol. Vol.8, No.3, e54499, JPN6021026700, 2013, pages 1 - 10, ISSN: 0004547143
"Significant Anti-Fibrotic Activity of Cenicriviroc, A Dual CCR2/CCR5 Antagonist, in a Rat Model of T", HEPATOLOGY, vol. 58 (6), JPN6019018469, 2013, pages 1381 - 1382, ISSN: 0004389537
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MOLECULAR PHARMACEUTICS, vol. 10, JPN6018045393, 13 August 2013 (2013-08-13), pages 4005 - 4015, ISSN: 0004389539
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto