Title:
ANTI-GDF15 ANTIBODIES
Document Type and Number:
Japanese Patent JP2019056018
Kind Code:
A
Abstract:
To provide anti-GDF15 antibodies.SOLUTION: Monoclonal antibodies that bind and inhibit activity of human GDF15 are disclosed. The antibodies can be used to treat a body weight loss, including cachexia, associated with the over-expression of human GDF15. The invention is based, in part, upon the discovery of a family of antibodies that specifically bind human GDF15 (hGDF15). The antibodies contain hGDF15 binding sites based on the CDRs of the antibodies. The antibodies can be used as therapeutic agents. When used as therapeutic agents, the antibodies are engineered, e.g., humanized, to reduce or eliminate an immune response when being administered to a human patient.SELECTED DRAWING: None
Inventors:
LORENA LERNER
SANDRA ABBOTT
BAI AILIN
CHEN TING
MARIA ISABEL CHIU
LIU QING
LAURA POLING
TAO NIANJUN
SOLLY WEILER
WENG ZHIGANG
WINSTON JR WILLIAM M
GYURIS JENO
SANDRA ABBOTT
BAI AILIN
CHEN TING
MARIA ISABEL CHIU
LIU QING
LAURA POLING
TAO NIANJUN
SOLLY WEILER
WENG ZHIGANG
WINSTON JR WILLIAM M
GYURIS JENO
Application Number:
JP2019007928A
Publication Date:
April 11, 2019
Filing Date:
January 21, 2019
Export Citation:
Assignee:
AVEO PHARMACEUTICALS INC
International Classes:
C07K16/22; A61K38/02; A61K39/395; A61K45/00; A61P1/14; A61P3/04; A61P7/00; A61P21/00; C12N15/13; C12N15/62; C12N15/63; C12P21/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto