Title:
ZIRCONIUM LABELING METHOD
Document Type and Number:
Japanese Patent JP2019112309
Kind Code:
A
Abstract:
To suppress the generation of nonbonding radioactive zirconium and increase the radiochemical yield of radioactive zirconium.SOLUTION: Provided is a zirconium labeling method, by which radioactive zirconium is bonded to a chelating agent in a reaction solution containing a tracer molecule bonded with the chelating agent and radioactive zirconium, the method being characterized in that the pH of the reaction solution is kept equal to or greater than 0 and equal to or less than 2 in the reaction between the radioactive zirconium and the chelating agent. The tracer molecule is a peptide or a low molecular organic compound and the chelating agent is a deferoxamine (DFO).SELECTED DRAWING: Figure 1
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Inventors:
IMURA RYOTA
Application Number:
JP2017244342A
Publication Date:
July 11, 2019
Filing Date:
December 20, 2017
Export Citation:
Assignee:
JFE ENG CORP
International Classes:
C07K1/13; A61K51/04; A61K51/06; A61K51/08; C07B59/00; C07C335/20; G01N33/60
Domestic Patent References:
| JP2008214551A | 2008-09-18 | |||
| JP2015134693A | 2015-07-27 | |||
| JP2016142599A | 2016-08-08 | |||
| JP2004286739A | 2004-10-14 | |||
| JP2014081213A | 2014-05-08 | |||
| JP2016060726A | 2016-04-25 |
Other References:
THE JOURNAL OF NUCLEAR MEDICINE, 2015, VOL.56, NO.10, PP.1569-1574, SUPPLEMENTAL DATA, JPN6021002690, ISSN: 0004434020
NATURE PROTOCOLS, 2010, VOL.5, NO.4, PP.739-743, JPN6021002691, ISSN: 0004434021
NATURE PROTOCOLS, 2010, VOL.5, NO.4, PP.739-743, JPN6021002691, ISSN: 0004434021
Attorney, Agent or Firm:
Sakai International Patent Office