Title:
MOUSE FcγRII SPECIFIC Fc ANTIBODY
Document Type and Number:
Japanese Patent JP2019142843
Kind Code:
A
Abstract:
To provide Fc variants that selectively bind to mouse FcγRII, which are useful for determining the effects in humans of Fc variants that selectively bind to FcγRIIb, and to provide methods for predicting human action of a polypeptide comprising an Fc variant that selectively binds to human FcγRIIb as compared to human FcγRIIa, using the Fc variant.SOLUTION: Provided is an Fc variant with significantly increased binding activity and/or binding selectivity for mouse FcγRII, by introducing an amino acid modification into an Fc region.SELECTED DRAWING: None
Inventors:
IGAWA TOMOYUKI
MURATA ERIKO
MIMOTO FUTA
MURATA ERIKO
MIMOTO FUTA
Application Number:
JP2019013918A
Publication Date:
August 29, 2019
Filing Date:
January 30, 2019
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
C07K16/00; A61K39/395; A61P37/06
Domestic Patent References:
| JP2008505174A | 2008-02-21 |
Foreign References:
| US20080206867A1 | 2008-08-28 |
Attorney, Agent or Firm:
Masao Haruna
Hatsushi Shimizu
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Hatsushi Shimizu
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto