Title:
CARBAMATE COMPOUNDS, AND PRODUCTION AND USE THEREOF
Document Type and Number:
Japanese Patent JP2019142891
Kind Code:
A
Abstract:
To provide compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as therapeutic agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent.SOLUTION: The invention provides carbamate compounds such as 1,1,1,3,3,3-hexafluoropropan-2-yl 4-((5-(4-methoxyphenyl)isoxazol-3-yl)methyl)piperazine-1-carboxylate.SELECTED DRAWING: None
Inventors:
JUSTIN S CISAR
CHERYL A GRICE
TODD K JONES
MICAH J NIPHAKIS
CHANG JAE WON
KENNETH M LUM
BENJAMIN F CRAVATT
CHERYL A GRICE
TODD K JONES
MICAH J NIPHAKIS
CHANG JAE WON
KENNETH M LUM
BENJAMIN F CRAVATT
Application Number:
JP2019065079A
Publication Date:
August 29, 2019
Filing Date:
March 28, 2019
Export Citation:
Assignee:
ABIDE THERAPEUTICS INC
SCRIPPS RESEARCH INST
SCRIPPS RESEARCH INST
International Classes:
C07D317/58; A61K31/4965; A61K31/4985; A61K31/5377; A61P3/04; A61P25/28; A61P29/00; A61P35/00; C07D205/04; C07D207/14; C07D213/38; C07D231/12; C07D231/16; C07D231/56; C07D241/04; C07D261/08; C07D263/32; C07D307/79; C07D471/04
Domestic Patent References:
| JP6253823B2 | 2017-12-27 | |||
| JP6514303B2 | 2019-05-15 |
Foreign References:
| WO2011151808A1 | 2011-12-08 | |||
| US20110275650A1 | 2011-11-10 |
Other References:
LONG, JONATHAN Z. ET AL.: "Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid Hy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 4, JPN6015045595, 2010, pages 1830 - 1842, XP002616518, ISSN: 0004220902, DOI: 10.1021/jm9016976
Attorney, Agent or Firm:
Kazuhiro Kiyohara