Title:
LINGO-2 ANTAGONISTS FOR TREATMENT OF CONDITIONS INVOLVING MOTOR NEURONS
Document Type and Number:
Japanese Patent JP2019150055
Kind Code:
A
Abstract:
To provide LINGO-2 antagonists for treatment of conditions involving motor neurons.SOLUTION: The invention provides methods of treating diseases, disorders or injuries involving motor neuron survival and axonal growth, including amyotrophic lateral sclerosis, by administration of a LINGO-2 antagonist. An exemplary method for promoting survival of a motor neuron comprises contacting the motor neuron with an effective amount of composition containing a LINGO-2 antagonist, the LINGO-2 antagonist selected from the group consisting of: (i) a soluble LINGO-2 polypeptide; (ii) a LINGO-2 antibody or antigen-binding fragment thereof; (iii) a LINGO-2 antagonist polynucleotide; (iv) a LINGO-2 aptamer; and (v) a combination of two or more of the LINGO-2 antagonists.SELECTED DRAWING: None
Inventors:
MI SHA
BLAKE R PEPINSKY
BLAKE R PEPINSKY
Application Number:
JP2019095977A
Publication Date:
September 12, 2019
Filing Date:
May 22, 2019
Export Citation:
Assignee:
BIOGEN MA INC
International Classes:
C12N15/13; A61K31/7088; A61K31/7105; A61K31/713; A61K35/12; A61K35/76; A61K35/761; A61K35/763; A61K38/17; A61K39/395; A61K47/56; A61K47/60; A61K47/61; A61K47/64; A61K47/68; A61K48/00; A61P21/00; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P43/00; C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/113; C12N15/115; C12N15/62; C12N15/86; C12N15/861; C12N15/863; C12N15/864; C12N15/866; C12N15/867; C12N15/869
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita