Title:
CRYSTALLINE FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS OF N-(4-((3-(2-AMINO-4-PYRIMIDINYL)-2-PYRIDINYL)OXY)PHENYL)-4-(4-METHYL-2-THIENYL)-1-PHTHALAZINAMINE AND USES THEREOF
Document Type and Number:
Japanese Patent JP2019189615
Kind Code:
A
Abstract:
To provide solid crystalline forms of salts of N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine, and pharmaceutical compositions, preparation methods and uses thereof.SOLUTION: The invention provides crystalline forms of pharmaceutically acceptable salts of AMG 900 having the formula in the figure. The invention further provides uses of the crystalline forms and compositions for treating cancer, including various types of solid tumors and hematologic cancer including melanoma and leukemia.SELECTED DRAWING: Figure 4
Inventors:
MARY CHAVES
MATTHEW BIO
MATTHEW PETERSON
MATTHEW BIO
MATTHEW PETERSON
Application Number:
JP2019099082A
Publication Date:
October 31, 2019
Filing Date:
May 28, 2019
Export Citation:
Assignee:
AMGEN
International Classes:
C07D409/14; A61K31/506; A61P11/00; A61P13/08; A61P15/08; A61P15/14; A61P35/00; A61P35/02
Domestic Patent References:
| JP2009528268A | 2009-08-06 | |||
| JP6634016B2 | 2020-01-22 |
Other References:
Ｃ．Ｇ．ＷＥＲＭＵＴＨ編, 最新 創薬化学 下巻, JPN6014029314, 1999, pages 347 - 365, ISSN: 0004262451
小嶌隆史: "医薬品開発における結晶性選択の効率化を目指して", 薬剤学, vol. 68, no. 5, JPN6009053757, 1 September 2008 (2008-09-01), pages 344 - 349, ISSN: 0004262452
芦澤一英 編, 医薬品の多形現象と晶析の科学, JPN6012027421, 20 September 2002 (2002-09-20), pages 312 - 317, ISSN: 0004262453
CAIRA M R, TOPICS IN CURRENT CHEMISTRY, vol. V198, JPN5006012237, 1998, pages 163 - 208, ISSN: 0004262454
PAYTON M; BUSH T L; CHUNG G ET AL: "PRECLINICAL EVALUATION OF AMG 900, A NOVEL POTENT AND HIGHLY SELECTIVE PAN-AURORA 以下備考", CANCER RESEARCH, vol. VOL:70 NR:23, JPN5016012171, 2010, pages 9846 - 9854, ISSN: 0004262455
HUANG LIYUE; BE XUHAI; BERRY LOREN ET AL: "IN VITRO AND IN VIVO PHARMACOKINETIC CHARACTERIZATIONS OF AMG 900, AN ORALLY 以下備考", XENOBIOTICA, vol. VOL:41 NR:5, JPN5016012172, 2011, pages 400 - 408, ISSN: 0004262456
小嶌隆史: "医薬品開発における結晶性選択の効率化を目指して", 薬剤学, vol. 68, no. 5, JPN6009053757, 1 September 2008 (2008-09-01), pages 344 - 349, ISSN: 0004262452
芦澤一英 編, 医薬品の多形現象と晶析の科学, JPN6012027421, 20 September 2002 (2002-09-20), pages 312 - 317, ISSN: 0004262453
CAIRA M R, TOPICS IN CURRENT CHEMISTRY, vol. V198, JPN5006012237, 1998, pages 163 - 208, ISSN: 0004262454
PAYTON M; BUSH T L; CHUNG G ET AL: "PRECLINICAL EVALUATION OF AMG 900, A NOVEL POTENT AND HIGHLY SELECTIVE PAN-AURORA 以下備考", CANCER RESEARCH, vol. VOL:70 NR:23, JPN5016012171, 2010, pages 9846 - 9854, ISSN: 0004262455
HUANG LIYUE; BE XUHAI; BERRY LOREN ET AL: "IN VITRO AND IN VIVO PHARMACOKINETIC CHARACTERIZATIONS OF AMG 900, AN ORALLY 以下備考", XENOBIOTICA, vol. VOL:41 NR:5, JPN5016012172, 2011, pages 400 - 408, ISSN: 0004262456
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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