Title:
METHODS FOR REDUCING RISKS ASSOCIATED WITH HEART FAILURE AND FACTORS ASSOCIATED THEREWITH
Document Type and Number:
Japanese Patent JP2019194193
Kind Code:
A
Abstract:
To provide compositions for preventing or treating heart failure in mammalian subjects, for reducing risk factors related to heart failure and/or reducing likelihood or severity of heart failure.SOLUTION: Disclosed herein is a composition comprising a therapeutically effective amount of a peptide D-Arg-2',6'-Dmt-Lys-Phe-NHor pharmaceutically acceptable salt thereof for reducing level(s) of one or more of C-reactive protein, reactive oxygen species, interleukin 6, TNFα, cardiac troponin I, NT-pro BNP, expression levels of MLCL AT1 and ALCAT1 and/or increasing Taz1 expression in a mammalian subject in need thereof.SELECTED DRAWING: Figure 1
Inventors:
D TRAVIS WILSON
SABBAH HANI N
SABBAH HANI N
Application Number:
JP2019104270A
Publication Date:
November 07, 2019
Filing Date:
June 04, 2019
Export Citation:
Assignee:
STEALTH BIOTHERAPEUTICS CORP
FORD HENRY HEALTH SYSTEM
FORD HENRY HEALTH SYSTEM
International Classes:
A61K38/07; A61K45/00; A61P1/02; A61P5/14; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P25/30; A61P25/32; A61P29/00; A61P31/12; A61P43/00
Attorney, Agent or Firm:
Koichi Tsujii
Kazuo Yamazaki
Satsuki Ichikawa
Kunimitsu Komatsu
Kazuo Yamazaki
Satsuki Ichikawa
Kunimitsu Komatsu