Title:
COMPOSITIONS, METHODS AND KITS FOR TREATING COMPLEMENT-RELATED DISORDERS
Document Type and Number:
Japanese Patent JP2020019813
Kind Code:
A
Abstract:
To provide compositions and methods for treating complement-associated disorders.SOLUTION: Provided here are a composition, a method and a kit for treating a complement-related disorder in a subject by using: a protein comprising a fusion of at least two of CD46, CD55 and CD59 proteins, or a recombinant chimeric protein comprising at least two of CD46, CD55 and CD59 proteins, or a nucleic acid encoding such a protein. The composition negatively modulates classical and alternative complement pathways, thereby treating a complement-related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinemia, fetal loss, organ graft rejection, and cancer etc.SELECTED DRAWING: None
Inventors:
RAJENDRA KUMAR-SINGH
DEREK LEADERER
SIOBHAN CASHMAN
DEREK LEADERER
SIOBHAN CASHMAN
Application Number:
JP2019186857A
Publication Date:
February 06, 2020
Filing Date:
October 10, 2019
Export Citation:
Assignee:
UNIV TUFTS
International Classes:
A61K48/00; A61K9/127; A61K9/51; A61K35/76; A61K35/761; A61K35/763; A61K47/02; A61K47/30; A61K47/42; A61K47/44; A61K47/55; A61P1/04; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/00; A61P37/02; A61P37/08
Domestic Patent References:
| JP2011514329A | 2011-05-06 |
Foreign References:
| WO2012016162A2 | 2012-02-02 |
Other References:
J.REPROD.IMMUNOL.,2009,81(1),P.62-73, JPN6019026605, ISSN: 0004367348
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita