Title:
METHOD FOR FABRICATING T-CELL ADAPTED FOR ALLOGRAFT
Document Type and Number:
Japanese Patent JP2020114229
Kind Code:
A
Abstract:
To provide a method for preparing a manipulated T-cell so as to adapt for an objective of immunotherapy.SOLUTION: A method for preparing a manipulated T-cell includes: (a) a process of preparing a T-cell; and (b) a process of inhibiting expression of β2-microglobulin (B2M) and/or class II major histocompatibility complex transactivator (CIITA) in the T-cell by using rare-cutting endonuclease which can selectively inactivate a gene which codes the B2M and/or a gene which codes the CIITA by DNA cleavage.SELECTED DRAWING: None
More Like This:
Inventors:
LAURENT POIROT
DAVID SOURDIVE
PHILIPPE DUCHATEAU
JEAN-PIERRE CABANIOLS
DAVID SOURDIVE
PHILIPPE DUCHATEAU
JEAN-PIERRE CABANIOLS
Application Number:
JP2020051964A
Publication Date:
July 30, 2020
Filing Date:
March 24, 2020
Export Citation:
Assignee:
CELLECTIS
International Classes:
C12N5/10; A61K35/17; A61P31/12; A61P35/00; A61P35/02
Domestic Patent References:
| JPH09507753A | 1997-08-12 | |||
| JP2010518832A | 2010-06-03 | |||
| JP2007532549A | 2007-11-15 |
Foreign References:
| WO2013158292A1 | 2013-10-24 |
Other References:
J. IMMUNOL., vol. 177, JPN6019006587, 2006, pages 6129 - 6136, ISSN: 0004746875
TRENDS IN BIOTECHNOLOGY, vol. 31, no. 7, JPN6019006592, 2013, pages 397 - 405, ISSN: 0004746876
TRANSFUS. MED. HEMOTHER., vol. 40, JPN6019006596, 2013, pages 388 - 402, ISSN: 0004746877
PLOS ONE, vol. 7, no. 5, JPN6019006599, 2012, pages 36163, ISSN: 0004746878
TRENDS IN BIOTECHNOLOGY, vol. 31, no. 7, JPN6019006592, 2013, pages 397 - 405, ISSN: 0004746876
TRANSFUS. MED. HEMOTHER., vol. 40, JPN6019006596, 2013, pages 388 - 402, ISSN: 0004746877
PLOS ONE, vol. 7, no. 5, JPN6019006599, 2012, pages 36163, ISSN: 0004746878
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto