Title:
COMBINATION THERAPY FOR CANCER
Document Type and Number:
Japanese Patent JP2020128366
Kind Code:
A
Abstract:
To provide methods of treating, suppressing, or reducing the severity of a liver cancer in a subject.SOLUTION: The methods include administering to the subject a first amount of safranal or a pharmaceutically acceptable pro-drug thereof and administering to the subject a second amount of a TOP1 inhibitor. In some embodiments, the TOP1 inhibitor is irinotecan, topotecan, camptothecin, lamellarin D, and/or combinations thereof.SELECTED DRAWING: None
Inventors:
AMR AMIN
Application Number:
JP2019207383A
Publication Date:
August 27, 2020
Filing Date:
November 15, 2019
Export Citation:
Assignee:
UNIV UNITED ARAB EMIRATES
International Classes:
A61K31/11; A61K31/4745; A61K45/00; A61P1/16; A61P35/00; A61P35/04; A61P43/00
Other References:
AMIN, A., ET AL., HEPATOLOGY, vol. Vol.54, Issue 3, JPN6022032547, 2011, pages 857 - 867, ISSN: 0004845238
AMIN, A., PROCEEDINGS, vol. Vol.1, Issue 10, NPCPT 2017, JPN6022032546, 2017, pages 834, ISSN: 0004845239
ADJEI, P.N., ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 98, no. 11, JPN6022032551, 1996, pages 2588 - 2596, ISSN: 0004845240
ZHANG, J., ET AL., CANCER INVESTIGATION, vol. Vol.26, Issue 5, JPN6022032549, 2008, pages 456 - 463, ISSN: 0004845241
KIM, D.W., JOURNAL OF GASTROINTESTINAL ONCOLOGY, vol. 8, no. 2, JPN6022032548, 2017, pages 256 - 265, ISSN: 0004845242
AMIN, A., PROCEEDINGS, vol. Vol.1, Issue 10, NPCPT 2017, JPN6022032546, 2017, pages 834, ISSN: 0004845239
ADJEI, P.N., ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 98, no. 11, JPN6022032551, 1996, pages 2588 - 2596, ISSN: 0004845240
ZHANG, J., ET AL., CANCER INVESTIGATION, vol. Vol.26, Issue 5, JPN6022032549, 2008, pages 456 - 463, ISSN: 0004845241
KIM, D.W., JOURNAL OF GASTROINTESTINAL ONCOLOGY, vol. 8, no. 2, JPN6022032548, 2017, pages 256 - 265, ISSN: 0004845242
Attorney, Agent or Firm:
Creation International Patent Office