Title:
IMMUNE-MODIFYING PARTICLES FOR TREATMENT OF INFLAMMATION
Document Type and Number:
Japanese Patent JP2020172501
Kind Code:
A
Abstract:
To provide pharmaceutical compositions for treating cancer, inflammatory disease, or the like by enhancing a regulatory T cell (Treg) suppressor function so as to decrease the inflammatory response to self proteins, or by blocking the function of Tregs or reprogramming Tregs into effector T cells capable of an inflammatory immune response to a desired target.SOLUTION: A pharmaceutical composition comprises: negatively charged particles, such as polystyrene particles, diamond particles, poly(lactide-co-glycolide) copolymers, polylactic acid polymers, and poly(lactic-co-glycolic acid) copolymers, having a zeta potential of -100 mV to 0 mV; and a carrier; where the particles are free from attached peptides or antigenic moieties.SELECTED DRAWING: None
Inventors:
DANIEL GETTS
NICHOLAS KING
NICHOLAS KING
Application Number:
JP2020111775A
Publication Date:
October 22, 2020
Filing Date:
June 29, 2020
Export Citation:
Assignee:
COUR PHARMACEUTICALS DEV COMPANY
International Classes:
A61K31/745; A61K9/16; A61K31/765; A61K33/44; A61P17/02; A61P21/02; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/06
Foreign References:
| WO2012065153A2 | 2012-05-18 | |||
| WO2013032829A1 | 2013-03-07 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito