Title:
DIHYDROINDOLIZINON DERIVATIVE
Document Type and Number:
Japanese Patent JP2021011506
Kind Code:
A
Abstract:
To provide a compound which is a strong FXIa inhibitor, is excellent in oral absorbability, kinetics in blood, exhibits strong anticoagulant activity over long time after oral administration, and has deviation between anticoagulant activity and CYP inhibitory.SOLUTION: A compound represented by the general formula (I), wherein all symbols are described in the application, a salt thereof, a solvate thereof, a N-oxide body thereof, or a prodrug thereof are strong FXIa inhibitors, and can be useful prevention and/or treatment agents for thromboembolic diseases since they excellent in oral absorbability, kinetics in blood, exhibit strong anticoagulant activity over long time after oral administration, and have deviation between anticoagulant activity and CYP inhibitory.SELECTED DRAWING: None
Inventors:
TANAKA MOTOYUKI
KONDO TAKASHI
HIROOKA YASUO
NISHIYAMA TAIHEI
HIRAMATSU ATSUSHI
KODA TOMOYUKI
KAMIYAMA SHO
KONDO TAKASHI
HIROOKA YASUO
NISHIYAMA TAIHEI
HIRAMATSU ATSUSHI
KODA TOMOYUKI
KAMIYAMA SHO
Application Number:
JP2020185297A
Publication Date:
February 04, 2021
Filing Date:
November 05, 2020
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO
International Classes:
C07D471/04; A61K31/444; A61K31/519; A61P1/16; A61P7/02; A61P9/00; A61P9/10; A61P31/04; A61P43/00; C07D487/04
Foreign References:
| GB2497806A | 2013-06-26 |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kazumi Nakamura
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kazumi Nakamura