Title:
VASCULAR GRAFT AND METHOD FOR PRESERVING PATENCY OF THE SAME
Document Type and Number:
Japanese Patent JP2021058668
Kind Code:
A
Abstract:
To provide: vascular grafts capable of maintaining long-term patency; and methods for maintaining graft patency by using the same.SOLUTION: A vascular graft 200 comprises: a blood-contacting layer 210 formed of a first microporous biomaterial; a nonporous intermediate layer 220; and a tissue-interface layer 230 having a textured microporous surface that contacts host tissue when implanted, the tissue-interface layer being formed of a second microporous biomaterial, wherein the textured microporous surface is capable of reducing fibrotic capsular formation, and the second microporous biomaterial has interconnected pores having an open pore structure, the mean pore diameter of which is 10-100 micrometers. The intermediate layer exists between the blood-contacting layer and the tissue-interface layer. The textured microporous surface comprises peaks 230b and valleys 230a. The height of the peaks is greater than 200 microns and less than 1,000 microns, the tissue-interface layer comprises interconnected pores and adjacent pores have inter-pore openings of larger than 5 microns and smaller than 50 microns.SELECTED DRAWING: Figure 2
Inventors:
ANDREW J MARSHALL
MAX MAGINNESS
ADRIENNE ODA
BRANDT SCANLAN
MAX MAGINNESS
ADRIENNE ODA
BRANDT SCANLAN
Application Number:
JP2020217069A
Publication Date:
April 15, 2021
Filing Date:
December 25, 2020
Export Citation:
Assignee:
HEALIONICS CORP
International Classes:
A61L27/50; A61L27/40; A61L27/44; A61L27/56
Domestic Patent References:
| JPS6464650A | 1989-03-10 | |||
| JP2005505317A | 2005-02-24 |
Foreign References:
| US5354329A | 1994-10-11 | |||
| WO2011127395A1 | 2011-10-13 |
Attorney, Agent or Firm:
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai
Michiko Matsutani
Yasushi Ochiai