Title:
THIOL AND DISULFIDE-CONTAINING AGENTS FOR INCREASING MEIBOMIAN GLAND LIPID SECRETION
Document Type and Number:
Japanese Patent JP2021063083
Kind Code:
A
Abstract:
To provide methods for increasing the quantity of lipids secreted from meibomian glands useful for meibomian gland dysfunction and disorders resulting therefrom.SOLUTION: A method for increasing lipid secretion from a meibomian gland comprises topically administering to an eyelid margin of a patient in need thereof an ophthalmic composition comprising an ophthalmically acceptable carrier and a therapeutically effective amount of at least one agent which increases lipogenesis in the meibomian gland or lipid secretion from the meibomian gland, where the agent comprises a sulfhydryl group, a -SeH group, or a disulfide.SELECTED DRAWING: Figure 6
Inventors:
SHIMON AMSELEM
YAIR ALSTER
FRIEDMAN DORON
OMER RAFAELI
YAIR ALSTER
FRIEDMAN DORON
OMER RAFAELI
Application Number:
JP2020206141A
Publication Date:
April 22, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
AZURA OPHTHALMICS LTD
International Classes:
A61K31/145; A61K31/015; A61K31/095; A61K31/122; A61K31/17; A61K31/19; A61K31/198; A61K31/20; A61K31/203; A61K31/23; A61K31/327; A61K31/385; A61K31/40; A61K31/575; A61K31/60; A61K31/685; A61K31/69; A61K33/04; A61K45/00; A61P27/02; A61P43/00
Domestic Patent References:
| JP2010510961A | 2010-04-08 | |||
| JPH07233057A | 1995-09-05 | |||
| JP2015514722A | 2015-05-21 | |||
| JP2014518275A | 2014-07-28 | |||
| JP2010520210A | 2010-06-10 |
Foreign References:
| US20140171886A1 | 2014-06-19 | |||
| US20110104206A1 | 2011-05-05 | |||
| WO2006137426A1 | 2006-12-28 | |||
| WO2014078956A1 | 2014-05-30 |
Other References:
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, vol. 26, no. 4, JPN6020020529, 2010, pages 329 - 333, ISSN: 0004718088
日本結晶学会誌, vol. 56, no. 3, JPN6020020530, 2014, pages 186 - 193, ISSN: 0004718089
日本結晶学会誌, vol. 56, no. 3, JPN6020020530, 2014, pages 186 - 193, ISSN: 0004718089
Attorney, Agent or Firm:
Kazuhiro Kiyohara