Title:
COMPOSITIONS, KITS AND METHODS TO INDUCE ACQUIRED CYTORESISTANCE USING STRESS PROTEIN INDUCERS
Document Type and Number:
Japanese Patent JP2021130710
Kind Code:
A
Abstract:
To provide compositions, kits and methods for making it possible to induce acquired cytoresistance without causing injury to an organ.SOLUTION: A kit for protecting an organ from an injury comprises a therapeutically effective amount of heme protein, vitamin B12, iron or a combination thereof, where administration of the therapeutically effective amount of heme protein, vitamin B12, iron or a combination thereof to an organ protects the organ without causing any injury to the organ.SELECTED DRAWING: None
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Inventors:
RICHARD ZAGER
ALI C M JOHNSON
ALI C M JOHNSON
Application Number:
JP2021093465A
Publication Date:
September 09, 2021
Filing Date:
June 03, 2021
Export Citation:
Assignee:
HUTCHINSON FRED CANCER RES
International Classes:
A61K38/16; A61K31/409; A61K31/555; A61K31/714; A61K33/26; A61K38/42; A61K45/00; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P31/04; A61P43/00
Other References:
ZAGER; ET AL: "HEME PROTEIN-INDUCED TUBULAR CYTORESISTANCE: EXPRESSION AT THE PLASMA MEMBRANE LEVEL", KIDNEY INTERNATIONAL, vol. VOL:47, NR:5, JPN5017007979, May 1995 (1995-05-01), pages 1336 - 1345, ISSN: 0005006852
NATH; ET AL: "INDUCTION OF HEME OXYGENASE IS A RAPID,PROTECTIVE RESPONSE IN RHABDOMYOLYSIS IN THE RAT", J. CLIN. INVEST., vol. VOL:90, NR:1, JPN5017007977, July 1992 (1992-07-01), pages 267 - 270, XP055277901, ISSN: 0005006853
JOHNSON; ET AL: "PARENTERAL IRON FORMULATIONS DIFFERENTIALLY AFFECT MCP-1,HO-1 AND NGAL GENE EXPRESSION AND RENAL RES", AM. J. PHYSIOL. RENAL. PHYSIOL., vol. VOL:299, NR:2, JPN5017007975, August 2010 (2010-08-01), pages 426 - 435, ISSN: 0005006854
FREE RADICAL BIOLOGY & MEDICINE, vol. 51, JPN6019027067, 2011, pages 876 - 883, ISSN: 0005006855
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 105, no. 29, JPN6019027069, 22 July 2008 (2008-07-22), pages 10256 - 10261, ISSN: 0005006856
INTERNATIONAL JOURNAL OF BIOCHEMISTRY, vol. 20, no. 6, JPN6019027070, 1988, pages 543 - 558, ISSN: 0005006857
KAIZU; ET AL: "PRECONDITIONING WITH TIN-PROTOPORPHYRIN IX ATTENUATES ISCHEMIA/REPERFUSION INJURY IN THE RAT KIDNEY", KIDNEY INTERNATIONAL, vol. VOL:63,NR:4, JPN5017007981, April 2003 (2003-04-01), pages 1393 - 1403, ISSN: 0005006858
NATH; ET AL: "INDUCTION OF HEME OXYGENASE IS A RAPID,PROTECTIVE RESPONSE IN RHABDOMYOLYSIS IN THE RAT", J. CLIN. INVEST., vol. VOL:90, NR:1, JPN5017007977, July 1992 (1992-07-01), pages 267 - 270, XP055277901, ISSN: 0005006853
JOHNSON; ET AL: "PARENTERAL IRON FORMULATIONS DIFFERENTIALLY AFFECT MCP-1,HO-1 AND NGAL GENE EXPRESSION AND RENAL RES", AM. J. PHYSIOL. RENAL. PHYSIOL., vol. VOL:299, NR:2, JPN5017007975, August 2010 (2010-08-01), pages 426 - 435, ISSN: 0005006854
FREE RADICAL BIOLOGY & MEDICINE, vol. 51, JPN6019027067, 2011, pages 876 - 883, ISSN: 0005006855
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 105, no. 29, JPN6019027069, 22 July 2008 (2008-07-22), pages 10256 - 10261, ISSN: 0005006856
INTERNATIONAL JOURNAL OF BIOCHEMISTRY, vol. 20, no. 6, JPN6019027070, 1988, pages 543 - 558, ISSN: 0005006857
KAIZU; ET AL: "PRECONDITIONING WITH TIN-PROTOPORPHYRIN IX ATTENUATES ISCHEMIA/REPERFUSION INJURY IN THE RAT KIDNEY", KIDNEY INTERNATIONAL, vol. VOL:63,NR:4, JPN5017007981, April 2003 (2003-04-01), pages 1393 - 1403, ISSN: 0005006858
Attorney, Agent or Firm:
Kawaguchi International Patent Office