Title:
METHOD OF ESTIMATING PROTEASE RESISTANCE OF ARGININE RESIDUE IN TARGET MOLECULE, METHOD OF SYNTHESIZING PROTEASE-RESISTANT MOLECULES USING THE SAME, AND APPARATUS AND PROGRAM FOR ESTIMATING PROTEASE RESISTANCE OF ARGININE RESIDUE IN TARGET MOLECULE
Document Type and Number:
Japanese Patent JP2021158986
Kind Code:
A
Abstract:
To provide, e.g, a method of estimating the protease resistance of an arginine residue in a target molecule, for making it possible to estimate the resistance of an arginine residue to a protease in a target molecule having the arginine residue.SOLUTION: A method of estimating the protease resistance of an arginine residue in a target molecule comprises, in a dihedral angle Ramachandran plot in a main chain of a target molecule having an arginine residue, estimating the protease resistance of the arginine residue in accordance with the abundance ratio of the arginine residue in the region satisfying -180°≤φ≤-30°and 90°≤ψ≤180°.SELECTED DRAWING: Figure 12
Inventors:
OSHIMA KANJI
KITA HIROSHI
KITA HIROSHI
Application Number:
JP2020063929A
Publication Date:
October 11, 2021
Filing Date:
March 31, 2020
Export Citation:
Assignee:
KANEKA CORP
International Classes:
C12Q1/37
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda