APREPITANT ORAL LIQUID FORMULATIONS

Title:

APREPITANT ORAL LIQUID FORMULATIONS

Document Type and Number:

Japanese Patent JP2021169504

Kind Code:

A

Abstract:

To provide improved oral liquid aprepitant formulations that have aprepitant particles in a suspension for extended time without agglomeration and concomitant precipitation, and a method of producing the same.SOLUTION: A method of producing a stabilized aqueous suspension of aprepitant for oral administration comprises: combining a pharmaceutically effective amount of aprepitant particles, hydroxypropyl methylcellulose and sodium dodecylsulfate with an acidic aqueous buffer solution such as citric acid to form a stabilized aqueous suspension, where the aprepitant particles have an average particle size of less than 0.5 micron; and packaging the stabilized aqueous suspension in a form suitable for oral administration; where the hydroxypropyl methylcellulose is present in the stabilized aqueous suspension in an amount of 4.0-8.0 mg/g, and where the sodium dodecylsulfate is present in the stabilized aqueous suspension in an amount of 1.0-4.0 mg/g.SELECTED DRAWING: None

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Inventors:

UDAYA TOTI
SHYAMPRASAD MUKUNDAN
SASANK CHAITANYA KUNADHARAJU
TUSHAR HINGORANI
KUMARESH SOPPIMATH
SATISH PEJAVER
NAVNEET PURI

Application Number:

JP2021117131A

Publication Date:

October 28, 2021

Filing Date:

July 15, 2021

Export Citation:

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Assignee:

INNOPHARMA INC

International Classes:

A61K31/5377; A61K9/10; A61K47/12; A61K47/20; A61K47/38; A61P1/08; A61P43/00

Domestic Patent References:

JPS61500788A	1986-04-24
JPH10504020A	1998-04-14
JP2006503868A	2006-02-02
JP2005516003A	2005-06-02
JP2009519235A	2009-05-14

Foreign References:

WO2011158053A1

2011-12-22

Other References:

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 285, JPN6018024883, 2004, pages 135 - 146, ISSN: 0004973848

Attorney, Agent or Firm:

Noh four
Maki Sato
Tatsuta Miyuki
Rie Ikeda

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