Title:
熱ショックタンパク質経路に関連する疾患の治療のための、修飾された糖基を有するビアリールアミド
Document Type and Number:
Japanese Patent JP2021524439
Kind Code:
A
Abstract:
熱ショックタンパク質経路に関連する疾患の治療のための、修飾された糖基を有するビアリールアミドおよびクマリンベースの化合物を提供する。化合物は、以下の式（I）、（II）、（III）、（IV）、および（V）を有し、変数は、本明細書で定義されている通りである。化合物の医薬組成物も提供される。修飾された糖基を有するこれらのビアリールアミドおよびクマリンベースの誘導体は、神経変性疾患および神経損傷性障害、例えば、糖尿病性末梢神経障害などの神経障害を含む疾患および障害の治療および予防に有用である。
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Inventors:
Jiang Shin
Bisnick melean
Bender Christopher F.
Bolton Gary
Capleys Bradley
Lee Chitase
Bisnick melean
Bender Christopher F.
Bolton Gary
Capleys Bradley
Lee Chitase
Application Number:
JP2020564427A
Publication Date:
September 13, 2021
Filing Date:
May 14, 2019
Export Citation:
Assignee:
Riata Pharmaceuticals, Inc.
International Classes:
C07H15/20; A61K9/08; A61K31/137; A61K31/165; A61K31/216; A61K31/351; A61K31/7034; A61K31/7048; A61P3/10; A61P25/00; A61P35/00; A61P43/00; C07D309/10; C07H17/075
Domestic Patent References:
| JP2015506982A | 2015-03-05 | |||
| JP2017521496A | 2017-08-03 |
Other References:
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Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto