Title:
【発明の名称】3-シアノ-4-アリ―ル-ピロ―ル類の製造方法
Document Type and Number:
Japanese Patent JP2505531
Kind Code:
B2
Abstract:
3-Cyano-4-arylpyrroles of the formula (I)
in which
Ar represents in each case substituted or unsubstituted heteroaryl or aryl,
are prepared by reacting alpha -cyanoacrylic acid derivatives of the formula (II)
in which
Ar has the abovementioned meaning and
R<1> represents amino or alkoxy
with isocyanoacetic esters of the formula (III)
in which
R<2> represents alkyl
in the presence of a base and, if desired, in the presence of a diluent and subjecting the DELTA <2>-pyrroline-2-carboxylic acid derivatives thus obtainable of the formula (IVa)
in which
X represents hydrogen or one equivalent of an inorganic or organic cation and
Ar has the abovementioned meaning
to oxidative decarboxylation in a 2nd step in the presence of a base and in the presence of a metal salt and, if desired, in the presence of a diluent.
Inventors:
DETOREFU BORUBEEBAA
Application Number:
JP12858488A
Publication Date:
June 12, 1996
Filing Date:
May 27, 1988
Export Citation:
Assignee:
BAYER AG
International Classes:
C07B61/00; C07D207/22; C07D207/34; (IPC1-7): C07D207/34; C07D207/22
Attorney, Agent or Firm:
Heiyoshi Odashima