Title:
【発明の名称】新規中間体の合成方法、ならびに該中間体を用いる3′‐アジド‐3′‐デオキシチミジンおよび類似体の合成方法
Document Type and Number:
Japanese Patent JP2619726
Kind Code:
B2
Abstract:
PCT No. PCT/FR89/00018 Sec. 371 Date May 4, 1990 Sec. 102(e) Date May 4, 1990 PCT Filed Jan. 19, 1989.The invention relates to a process for preparing a compound of formula (I) I in which R1 is H, an alkyl radical or an alkoxy, hydroxyalkyl or halogen radical, and R3 is N3 or a CN radical, characterized in that a compound of formula (II): II is reacted with a phosphine derivative and an azodicarboxylic acid diester and a carboxylic acid R2-COOH in a solvent compatible with the reaction conditions, to form the compound of formula (III): III which, after separation if required, is opened in the presence of an azide or a cyanide in a solvent compatible with the reaction conditions, and the compound of formula (I) is then isolated from the reaction medium after deprotection of the 5'-position.
Inventors:
Chernecki, Stanislas
Valerie Jean-Marc
Ville, guy
Valerie Jean-Marc
Ville, guy
Application Number:
JP50147789A
Publication Date:
June 11, 1997
Filing Date:
January 19, 1989
Export Citation:
Assignee:
Universite Pierre Emery Curie (Paris Sith)
International Classes:
C07H19/073; C07H19/06; (IPC1-7): C07H19/073
Other References:
Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ ５２［４］Ｐ．１１９１−１１９６（１９７９）
Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ，１０１［２１］：１９２３７８ｃ Ｐ．８１３（１９８４）（Ｂｉｏｏｒｇ．Ｋｈｉｍ；１９８４，１０（５）Ｐ．６７０−６８０に対する抄録）
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ２７［１］Ｐ．１１−１４（１９８４）
Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ３５［９］Ｐ．２８６８−２８７７（１９７０）
Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ，１０１［２１］：１９２３７８ｃ Ｐ．８１３（１９８４）（Ｂｉｏｏｒｇ．Ｋｈｉｍ；１９８４，１０（５）Ｐ．６７０−６８０に対する抄録）
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ２７［１］Ｐ．１１−１４（１９８４）
Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ３５［９］Ｐ．２８６８−２８７７（１９７０）
Attorney, Agent or Firm:
Akio Saruwatari (1 person outside)