Title:
【発明の名称】キラルテトラロンの製造方法
Document Type and Number:
Japanese Patent JP2686366
Kind Code:
B2
Abstract:
PCT No. PCT/IB94/00263 Sec. 371 Date May 29, 1996 Sec. 102(e) Date May 29, 1996 PCT Filed Sep. 2, 1994 PCT Pub. No. WO95/15299 PCT Pub. Date Jun. 8, 1995A process for preparing the chiral (4S)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is disclosed wherein racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is asymmetrically reduced by contacting the racemic tetralone with an asymmetric reagent to produce a mixture of cis and trans alcohols, separating the cis from the trans alcohols, and oxidizing the (4S) enantiomer of the resulting cis and trans alcohols. Also disclosed are novel intermediates used in the synthesis of the above chiral tetralone.
Inventors:
Quarry, George Jay
Application Number:
JP51227695A
Publication Date:
December 08, 1997
Filing Date:
September 02, 1994
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07B53/00; C07B61/00; C07C29/143; C07C35/36; C07C35/52; C07C45/29; C07C45/30; C07C45/67; B01J31/22; C07C49/697; (IPC1-7): C07C35/52; B01J31/22; C07B53/00; C07C29/143; C07C45/29; C07C49/697
Attorney, Agent or Firm:
Kyozo Yuasa (5 people outside)