Title:
【発明の名称】1,2,4―トリオキサン誘導体
Document Type and Number:
Japanese Patent JP2690012
Kind Code:
B2
Abstract:
1,2,4-trioxane derivatives of formula: (wherein each of the subscripts m and n is equal to 0 or 1; the symbol Z represents an epoxide oxygen atom at the 5,6 or 6,7 positions, or a pair of electrons forming a double bond at the 5,6 or 6,7 positions; each of the symbols Ar<1> and Ar<2>, being the same or different, represents an aromatic group which is optionally substituted; each of the symbols R<1> and R<2>, being the same or different, represents a linear or branched alkyl group, which is optionally substituted, or R<1> and R<2>, taken together with the carbon atom to which they are attached, form an alicyclic group which is optionally interrupted by one or more oxygen, sulphur or nitrogen atoms and which group is optionally substituted with one or more alkyl or aryl groups, or one or more functional groups; and each of X and Y, being the same or different, represents a hydrogen atom or a functional group which contains oxygen, nitrogen or sulphur) are of use in the treatment of tropical diseases including malaria and have other physiological activities.
Inventors:
Charles W. Jefford
Application Number:
JP8022888A
Publication Date:
December 10, 1997
Filing Date:
March 31, 1988
Export Citation:
Assignee:
Oxako Societe Anonym
International Classes:
A61K31/335; A61K31/357; A61P33/02; C07D323/04; C07D493/04; C07D493/18; (IPC1-7): C07D323/04; A61K31/335; C07D493/18
Other References:
ACTA CRYSTALLOGR=1987
J CHEM SOC CHEM COMMUN=1984
J CHEM SOC CHEM COMMUN=1984
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)