Title:
【発明の名称】アクリジン誘導体
Document Type and Number:
Japanese Patent JP2783680
Kind Code:
B2
Abstract:
There are provided compounds of the general formula (I) wherein R<0> represents a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy, C1-4alkylthio, amino or nitro group; p represents 1; or when R<0> represents C1-4alkoxy may also represent 2 or 3; R<1> represents a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or C1-4alkylthio group; R<2> represents a hydrogen atom or a C1-4alkyl group; A represents an oxygen or a sulphur atom, a bond or a group (CH2)1NR<9> (where 1 represents zero or 1 and R<9> represents a hydrogen atom or a methyl group); B represents a C1-4alkylene chain optionally substituted by a hydroxyl group, except that the hydroxyl group and moiety A cannot be attached to the same carbon atom when A represents an oxygen or sulphur atom or a group (CH2)1NR<9>, or when A represents a bond B may also represent a C2-4alkenylene chain; R<3> represents a hydrogen atom or a C1-4alkyl group; m represents 1 or 2; R<4> represents a hydrogen or a halogen atom, or a C1-4alkyl, C1-4alkoxy or C1-4alkylthio group; R<5> represents a hydrogen atom or a C1-4alkoxy group; R<6> represents a hydrogen atom or a C1-4alkyl or C1-4alkoxy group R<7> represents a hydrogen atom or R<3> and R<7> together form a group -(CH2)n-where n represents 1 or 2; R<8> represents a hydrogen atom or a C1-4alkoxy group; the group is attached at the benzene ring 3 or 4 position relate to the carboxamide substituent, provided that when the group is attached at the benzene ring 3 position then R<6> must be attached at the benzene ring 6 position; and salts and solvates thereof. The novel compounds of formula (I) can sensitize multidrug-resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an antitumour drug.
More Like This:
Inventors:
DEYUMETORU BERUNAARU ANDORE
DODEITSUKU NURINA
DODEITSUKU NURINA
Application Number:
JP50167192A
Publication Date:
August 06, 1998
Filing Date:
January 07, 1992
Export Citation:
Assignee:
RABO* GURAKUSO SA
International Classes:
A61K31/473; A61P35/00; A61P43/00; A61K31/47; C07C205/11; C07C205/26; C07C205/37; C07C205/56; C07D219/04; C07D219/06; C07D401/12; (IPC1-7): C07D219/06; A61K31/47; C07D401/12
Attorney, Agent or Firm:
Kazuo Sato (2 outside)