Title:
【発明の名称】新規ビタミンD類似体
Document Type and Number:
Japanese Patent JP2807086
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I), in which formula, n is 0 or 1, m is 0 or an integer from 1-7, R<1> and R<2> (which may be the same or different) stand for hydrogen or C1-C8-hydrocarbyl, or, taken together with the carbon bearing the hydroxyl group (starred in formula I), R<1> and R<2> can form a saturated or unsaturated C3-C8 carbocyclic ring. In addition, R<1> and/or R<2> and/or one of the m carbons designatedby the " DEG " may be optionally substituted with a hydroxyl group or one or more chlorine or fluorine atom(s); and finally one of the carbons designated " DEG " may optionally be substituted by one or two C1-C2 alkyl group(s); and derivatives of the compounds of formula I in which one or more hydroxy have been transformed into -O-acyl or -O-glycosyl or phosphate ester groups; such masked groups being hydrolyzable in vivo. The present compounds find use in both the human and veterinary practice in the treatment and prophylaxis of autoimmune diseases (including diabetes mellitus), hypertension, acne, alopecia, skin ageing, imbalance in the imune system, inflammatory diseases such as rheumatoid arthritis and asthma as well as diseases characterized by abnormal cell differentiation and/or cell proliferation, such as e.g. psoriasis and cancer.
Inventors:
Calvary, Martin John
Binerup, Ernst Tonal
Binerup, Ernst Tonal
Application Number:
JP50993690A
Publication Date:
September 30, 1998
Filing Date:
June 19, 1990
Export Citation:
Assignee:
Leo Pharmaceutical Products Limited A/S
International Classes:
A61P9/12; A61P11/00; A61P17/00; A61K31/59; A61P29/00; A61P35/00; A61P37/00; C07C401/00; C07F7/18; (IPC1-7): C07C401/00; A61K31/59
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)