Title:
【発明の名称】光学活性アルコール類の製造方法
Document Type and Number:
Japanese Patent JP2962668
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To safety obtain the subject compound useful as a synthetic raw material for medicines and a liquid crystal material, etc., in high yield and optical purity by ready operation without requiring hydrogen by subjecting a carbonyl compound to hydrogen transfer type asymmetric reduction in the presence of a specific asymmetric reduction catalyst and a hydrogen donating compound. SOLUTION: (C) A carbonyl compound such as a compound of formula I [R<1> is a (substituted) aromatic monocyclic group, a polycyclic hydrocarbon group, etc.; R<2> is H, a (substituted) (un)saturated chain or cyclic hydrocarbon group, etc.] is subjected to hydrogen transfer type asymmetric reduction in the presence of (A) a three-component asymmetric reduction catalyst composed of a transition metal complex (e.g. a complex of a VIII group metal), a base [e.g. an alkali (alkaline earth) metal hydroxide or its (quaternary ammonium) salt] and an optically active nitrogen-containing compound (e.g. optically active amine derivative) and (B) a hydrogen-donating organic or inorganic compound [e.g. an alcohol, formic acid (salt), a hydrocarbon compound, a heterocyclic compound, hydroquinone or phosphorous acid] to provide the objective optically active alcohols such as a compound of formula II.
Inventors:
IKARYA TAKAO
TAKEHARA JUN
HASHIGUCHI SHOHEI
FUJII AKIO
NOYORI RYOJI
TAKEHARA JUN
HASHIGUCHI SHOHEI
FUJII AKIO
NOYORI RYOJI
Application Number:
JP31830395A
Publication Date:
October 12, 1999
Filing Date:
December 06, 1995
Export Citation:
Assignee:
KAGAKU GIJUTSU SHINKO JIGYODAN
NIPPON KOKAN KK
MITSUBISHI KAGAKU KK
TAKEDA YAKUHIN KOGYO KK
NIPPON KOKAN KK
MITSUBISHI KAGAKU KK
TAKEDA YAKUHIN KOGYO KK
International Classes:
C07D215/18; B01J31/16; C07B41/02; C07B61/00; C07C29/136; C07C31/02; C07C31/13; C07C33/02; C07C33/05; C07C33/18; C07C35/23; C07C37/20; C07C39/02; C07C39/12; C07C39/18; C07C67/31; C07C69/732; C07C255/56; C07D311/22; C07D495/04; (IPC1-7): C07C29/136; C07B41/02; C07C31/02; C07C31/13; C07C33/02; C07C33/05; C07C33/18; C07C35/23; C07C37/20; C07C39/02; C07C39/12; C07C39/18; C07C67/31; C07C69/732; C07C255/56; C07D215/18; C07D311/22; C07D495/04
Other References:
Ｃｈｅｍｉｃａｌ Ｒｅｖｉｅｗｓ，１９９２，Ｖｏｌ．９２，Ｎｏ．５，ｐ．１０５１−１０６９
Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９９５，１１７，ｐ．２６７５−２６７６
Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９９５，１１７，ｐ．２６７５−２６７６
Attorney, Agent or Firm:
Toshio Nishizawa