Title:
【発明の名称】2,4-ジクロロピリジン類を2-アリールオキシ-4-クロロピリジン類へ変換する方法
Document Type and Number:
Japanese Patent JP2989015
Kind Code:
B2
Abstract:
This invention relates to a process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines, comprising reacting a compound of formula (I), wherein R1 is (C1-C4)alkyl; R2 is methyl or ethyl; and R3, R4 and R5 are selected, independently, from (C1-C4)alkyl and (C1-C4)alkoxy; or a pharmaceutically acceptable salt thereof; comprising reacting a compound of formula (II), wherein R1 and R2 are defined as above, with a compound of formula (III), wherein R3, R4 and R5 are defined as above, in the presence of a base that is capable of deprotonating the compound of formula (III), optionally in the presence of an organometallic halide or oxide and a suitable solvent, and then optionally converting the resulting compound of formula (I) into a pharmaceutically acceptable salt of such compound.
Inventors:
Chen, Yupin El
Luggelli, Sally Gut
Luggelli, Sally Gut
Application Number:
JP52977096A
Publication Date:
December 13, 1999
Filing Date:
June 06, 1995
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07D213/64; B01J27/122; C07D213/643; (IPC1-7): C07D213/64
Domestic Patent References:
| JP285225A | ||||
| JP9507249A |
Other References:
【文献】米国特許3637720(US,A)
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)