Title:
【発明の名称】オキソキノリンカルボン酸誘導体の製造中間体
Document Type and Number:
Japanese Patent JP2992033
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound useful as a synthetic intermediate for a quinolonecarboxylic acid derivative having excellent antimicrobial activities. SOLUTION: This compound is represented by formula I (R<1> is a fluorine- substituted methoxy; X is a halogen), e.g. 3-difluoromethoxy-6-nitro-2,4,5- trifluorobenzoic acid. The compound represented by formula I is obtained by decarboxylating 4-hydroxy-3,5,6-trifluorophthalic acid in water or an aqueous solvent under heating, dissolving the resultant 3-hydroxy-2,4,5-trifluorobenzoic acid in concentrated sulfuric acid, dropping concentrated nitric acid into the prepared solution under stirring and cooling with ice, stirring the reactional liquid, allowing the reactional liquid to cool, then pouring the cooled reactional liquid into ice water, extraction-treating the mixture, washing the organic layer with a saturated saline solution, then drying the washed organic layer with anhydrous sodium sulfate, subsequently distilling off the solvent under a reduced pressure and nitrating the resultant product. The compound represented by formula I can be used for synthesizing a compound represented by formula II (R<10a> is a lower alkyl; Z is nitro or amino), a compound represented by formula III and a compound represented by formula IV.
Inventors:
IWATA MASAYUKI
KIMURA TOMIO
INOE TERUHIKO
FUJIWARA YOSHIMI
KATSUBE TETSUTSUGU
KIMURA TOMIO
INOE TERUHIKO
FUJIWARA YOSHIMI
KATSUBE TETSUTSUGU
Application Number:
JP3253199A
Publication Date:
December 20, 1999
Filing Date:
February 10, 1999
Export Citation:
Assignee:
SANKYO KK
UBE KOSAN KK
UBE KOSAN KK
International Classes:
C07C205/59; (IPC1-7): C07C205/59
Attorney, Agent or Firm:
Akio Ohno