【発明の名称】タンパク質またはポリペプチド類とその製造法および中間化合物

Japanese Patent JP3173794

B2

The present invention provides a protein or polypeptide substance having at least one amino group bonded to a polyethyleneglycolosy group represented by the following general formula; R1 -(OCH2 CH2) n - O - (wherein R1 represents an optionally substituted cholesteryl group; and n represents a positive integer which is arbitrarily variable), and a method for producing said the protein or polypeptide. The present invention also provides a reactive polyethyleneglycol derivative as an intermediated for above the method. The chemically modified protein or polypeptide of the present invention never impairs bonding with a receptor and has a high plysiological activity. Then, a behaviors in vivo of these substance is improved. Now medical substances or drugs having a high pharmacological activity can be developed by using these substance.

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Suzuki Yosuke
Shuji Sato

JP52992795A

June 04, 2001

May 19, 1995

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Hisamitsu Pharmaceutical Co., Ltd.

A61P37/06; C07K1/107; C07K2/00; C07K14/62; C08G65/329; C08G65/333; C12N9/02; A61K38/00; (IPC1-7): C07K14/00; A61K38/28; A61P1/04; A61P3/10; C07K14/62; C08G65/321; C12N9/02

Toshio Nishizawa

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