Title:
【発明の名称】フィブリノーゲンレセプターアンタゴニスト
Document Type and Number:
Japanese Patent JP3322878
Kind Code:
B2
Abstract:
PCT No. PCT/US93/09750 Sec. 371 Date May 31, 1995 Sec. 102(e) Date May 31, 1995 PCT Filed Oct. 12, 1993 PCT Pub. No. WO94/08577 PCT Pub. Date Apr. 28, 1994 (a) (b) Novel fibrinogen receptor antagonists of the formula: X-Y-Z-Aryl-A-B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsubstituted or substituted with R5 and wherein S may be substituted with 0, 1 or 2 oxygen atoms; and X comprises various Nitrogen substituents including aromatic or nonaromatic systems; Y comprises, for example, alkyl or alkylaminocarbonylalkyl groups and Z and A are substituents which when present are independently chosen from alkyl or alkyloxyalkyl or other groups as defined herein; B is (a) or (b). The claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating or preventing thrombus formation.
Inventors:
Hartman, Yogyi Day
Bluff, Jiyoung Day
Egbertson, Melitsa S
Mark Gun, Dagan
Hoffman, William
Bluff, Jiyoung Day
Egbertson, Melitsa S
Mark Gun, Dagan
Hoffman, William
Application Number:
JP51021894A
Publication Date:
September 09, 2002
Filing Date:
October 12, 1993
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/38; A61K31/381; A61K31/4427; A61K31/4433; A61K31/445; A61K31/454; A61P7/02; C07C311/06; C07C311/19; C07D233/64; C07D333/38; C07D401/12; C07D409/06; C07D409/12; C07D413/12; (IPC1-7): C07D413/12
Domestic Patent References:
| JP4288051A | ||||
| JP2223543A | ||||
| JP2235853A |
Other References:
【文献】欧州特許出願公開478328(EP,A1)
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)