Title:
【発明の名称】三置換-および四置換グアニジン類およびそれらの興奮性アミノ酸アンタゴニストとしての用途
Document Type and Number:
Japanese Patent JP3341000
Kind Code:
B2
Abstract:
Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induced responses of the NMDA receptor by acting as blockers for the ion channel of the NMDA receptor-ion channel complex. These compounds thus exert neuroprotective activity and are useful in the therapeutic treatment of neuronal loss in hypoxia, hypoglycemia, brain or spinal cord ischemia, and brain or spinal chord trauma as well as being useful for the treatment of epilepsy, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, Down's Syndrome, Korsakoff's disease and other neurodegenerative disorders.
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Inventors:
Eccard Webber
John F Double Keena
John F Double Keena
Application Number:
JP2001154124A
Publication Date:
November 05, 2002
Filing Date:
May 23, 2001
Export Citation:
Assignee:
Oregon
International Classes:
A61K31/155; A61K31/37; A61P9/04; A61P9/10; A61P25/00; A61P25/08; A61P25/14; A61P25/26; A61P25/28; A61P43/00; B41J2/47; C07C279/02; C07D311/08; C07C279/18; C07D311/18; G03G15/16; (IPC1-7): C07C279/18; A61K31/155; A61K31/37; A61P9/04; A61P9/10; A61P25/00; A61P25/08; A61P25/14; A61P25/26; A61P25/28; A61P43/00; C07D311/08
Domestic Patent References:
| JP2500909A |
Foreign References:
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)