Title:
【発明の名称】新規なエポキシコハク酸アミド誘導体又はその塩
Document Type and Number:
Japanese Patent JP3410476
Kind Code:
B2
Abstract:
The invention relates an epoxysuccinamide derivative represented by a formula (I): wherein R<1> represents a hydrogen atom, an alkyl or aminoalkyl group, R<2> represents an aminoalkyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an aralkyl group which may be substituted, or an alkyl group substituted by a heterocyclic ring which may be substituted, or R<1> and R<2> may form a nitrogen-containing heterocyclic ring, which may be substituted, together with the adjacent nitrogen atoms, and R<3> and R<4> are the same or different from each other and independently represent a hydrogen atom, or an alkyl or aralkyl group, or a salt thereof, a preparation process thereof, and a medicine comprising such a derivative or salt as an active ingredient. This compound has a specific inhibitory activity for cathepsin L and family enzymes thereof, and is useful as an agent for preventing and treating metabolic osteopathy such as osteoporosis and hypercalcemia.
Inventors:
Tetsuji Asao
Tomohiro Yamashita
Suda Yoshimitsu
Shigeo Okajima
Yukio Tada
Nobuhiko Katsunuma
Shozo Yamada
Kazuhiko Shigeno
Atsuhiko Uemura
Tomohiro Yamashita
Suda Yoshimitsu
Shigeo Okajima
Yukio Tada
Nobuhiko Katsunuma
Shozo Yamada
Kazuhiko Shigeno
Atsuhiko Uemura
Application Number:
JP53559298A
Publication Date:
May 26, 2003
Filing Date:
April 17, 1998
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
C07D303/48; C07D303/40; (IPC1-7): C07D303/48; A61K31/335; A61P3/14; A61P19/08; A61P19/10; A61P35/04; A61P43/00
Domestic Patent References:
| JP8104683A | ||||
| JP8104684A | ||||
| JP11263783A |
Other References:
【文献】国際公開97/021694(WO,A1)
Attorney, Agent or Firm:
Arga Patent Office (5 outside)