Title:
【発明の名称】DERMATOPHAGOIDES(室内塵ダニ)アレルゲンのクローニング及び配列決定
Document Type and Number:
Japanese Patent JP3487852
Kind Code:
B2
Abstract:
The present invention features isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, the invention provides DNA encoding the major D. farinae allergens, Der f I and Der f II and DNA encoding the major D. pteronvssinus allergens, Der p I and Der p II. The present invention further relates to proteins and peptides encoded by the isolated D. farinae and D. pteronvssinus DNA, including proteins containing sequence polymorphisms. In addition, the proteins or peptides encoded by the isolated DNA, their use a diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens, are disclosed.
Inventors:
Thomas, Wayne Earl.
Chua, Coyan
Chua, Coyan
Application Number:
JP50754294A
Publication Date:
January 19, 2004
Filing Date:
September 10, 1993
Export Citation:
Assignee:
Tea W W Teleson Institute for Child Health Research
International Classes:
A61K39/35; A61K39/36; A61K39/395; A61P37/08; C07H21/04; C12N15/09; C07K14/435; C07K14/54; C12N15/12; C12P21/02; A61K38/00; C12R1/19; (IPC1-7): C07K14/435; A61K39/395; A61P37/08; C12N15/09; C12P21/02
Domestic Patent References:
| JP3254683A |
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)