Title:
【発明の名称】レニン阻害N-(2-アミノ-2-オキソエチル)ブタンジアミド誘導体
Document Type and Number:
Japanese Patent JP3490442
Kind Code:
B2
Abstract:
Disclosed herein are compounds of the formula: A-N(R<1>)C(O)CH2CHR<2>C(O)-B wherein A is R<3>R<4>NC(O)CH2 wherein, for example, R<3> is hydrogen or alkyl and R<4> is hydrogen, alkyl or a substituted alkyl such as 2-(2-pyridinyl)ethyl, or R<3> and R<4> together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino or thiomorpholino; R<1> is, for example, benzyl, alkyl or a substituted alkyl such as cyclohexylmethyl; R<2> is, for example, alkyl, cycloalkylmethyl, 1H-imidazol-4-ylmethyl, 4-thiazolylmethyl or (2-amino-4-thiazolyl)methyl; and B is a renin substrate transition state analog, for example, [1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]amino. The compounds inhibit renin activity and are indicated for the treatment of hypertension and congestive heart failure.
Inventors:
Laval Pierre
Simone Bruno
Simone Bruno
Application Number:
JP50854294A
Publication Date:
January 26, 2004
Filing Date:
September 15, 1993
Export Citation:
Assignee:
Boehringer Ingelheim (Canada) Limited
International Classes:
C07D295/18; A61K31/16; A61K31/165; A61K31/40; A61K31/4015; A61K31/415; A61K31/44; A61K31/4402; A61K31/4418; A61P9/12; A61P43/00; C07C233/18; C07C237/22; C07D207/26; C07D213/40; C07D233/64; C07D277/28; C07D277/30; C07D277/40; C07D295/185; C07D295/215; C07D417/12; (IPC1-7): C07C233/18; A61K31/16; A61K31/165; A61K31/40; A61K31/415; A61K31/44; A61P9/12; C07C237/22; C07D207/26; C07D213/40; C07D233/64; C07D277/28; C07D295/18
Domestic Patent References:
| JP532602A |
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)