Title:
プロテインキナーゼCのオリゴヌクレオチド変調
Document Type and Number:
Japanese Patent JP3553068
Kind Code:
B2
Abstract:
New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C alpha . Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C alpha . Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC alpha . Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed. Polynucleotide probes for PKC alpha are also disclosed.
Inventors:
Bennett, Sea Frank
Boggs, Russell Tea
Dean, Nicholas M
Boggs, Russell Tea
Dean, Nicholas M
Application Number:
JP50420195A
Publication Date:
August 11, 2004
Filing Date:
July 08, 1994
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
C12N15/09; A61K31/7088; A61K31/711; A61K31/712; A61K31/7125; A61K48/00; A61P29/00; A61P35/00; A61P43/00; C07H21/00; C07H21/04; C07K14/705; C12N5/10; C12N9/12; C12N15/113; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/573; G01N33/68; A61K38/00; (IPC1-7): C12N15/09; C12Q1/68
Other References:
Antisense Res.Dev., 1991年,1,p.35-42
Science, 1986年,233, p.859-866
J.Biol.Chem., 1993年,268, p.11946-11950
Exp.Cell Res., 1993年,205, p.52-58
Biochemistry, 1992年,31, p.10950-10954
Science, 1986年,233, p.859-866
J.Biol.Chem., 1993年,268, p.11946-11950
Exp.Cell Res., 1993年,205, p.52-58
Biochemistry, 1992年,31, p.10950-10954
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita